[The effect of icariin and astragalosid I on the proliferation and differentiation of bone marrow stromal cells].

Liu, HJ ; Wang, XP ; et al.

In: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, Jg. 29 (2006-10-01), Heft 10, S. 1062

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Objective: To observe the effects of icariin and astragalosid I on the proliferative and alkaline phosphatase (ALP) activity of dog bone marrow stromal cells (BMSCs).

Methods: The dog's BMSCs were isolated and cultured in vitro. The 3th generation BMSCs were treated with icariin or astragalosid I at the concentration of 50 ng/ml and compared with BMSCs of BMP-2 group and control group. The growth curves of BMSCs were drawn by 3-(4,5-dimiethylthiazole-2-yl)-2, 5-hiphenyl tetrazolium bromide (MTT) colorimetric assay every day from the 1st to the 8th day to estimate the proliferative ability of BMSCs. The curves of OD value of ALP excreted by BMSCs on the 1st, 3th, 6th, 10th and the 14th day were recorded to estimate the ALP activity of BMSCs.

Results: After the pertreatment with icariin and astragalosid I, the BMSCs acquired higher MTF values and higher ALP's OD values as compared with control group and the difference between experiment group and control group was statistically significant (P < 0.05).

Conclusion: Icariin and Astragealosid I can accelerate the proliferation and ALP excretion of BMSCs. At the same time, the osteogenesis ability of these cells is greatly improved.

Titel:	[The effect of icariin and astragalosid I on the proliferation and differentiation of bone marrow stromal cells].
Autor/in / Beteiligte Person:	Liu, HJ ; Wang, XP ; Lin, J ; Yu, YC ; Jiang, XQ ; Zhang, XL ; Zhou, ZT ; Zhang, WD
Link:	Zum Volltext
Zeitschrift:	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, Jg. 29 (2006-10-01), Heft 10, S. 1062
Veröffentlichung:	Guangzhou Shi : Guo jia yi yao guan li ju Zhong yao cai qing bao zhong xin zhan ; <i>Original Publication</i>: Guangzhou Shi : Guo jia yi yao guan li ju Zhong yao cai qing bao zhong xin zhan,, 2006
Medientyp:	academicJournal
ISSN:	1001-4454 (print)
Schlagwort:	Alkaline Phosphatase metabolism Animals Astragalus propinquus chemistry Bone Marrow Cells cytology Bone Marrow Cells metabolism Cell Differentiation drug effects Cells, Cultured Dogs Osteogenesis drug effects Plants, Medicinal chemistry Stromal Cells cytology Stromal Cells drug effects Stromal Cells metabolism Time Factors Bone Marrow Cells drug effects Cell Proliferation drug effects Drugs, Chinese Herbal pharmacology Flavonoids pharmacology Saponins pharmacology Triterpenes pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Chinese Publication Type: Journal Article Language: Chinese [Zhong Yao Cai] 2006 Oct; Vol. 29 (10), pp. 1062-5. MeSH Terms: Bone Marrow Cells / drug effects ; Cell Proliferation / drug effects ; Drugs, Chinese Herbal / pharmacology ; Flavonoids / pharmacology ; Saponins / pharmacology ; Triterpenes / pharmacology ; Alkaline Phosphatase / metabolism ; Animals ; Astragalus propinquus / chemistry ; Bone Marrow Cells / cytology ; Bone Marrow Cells / metabolism ; Cell Differentiation / drug effects ; Cells, Cultured ; Dogs ; Osteogenesis / drug effects ; Plants, Medicinal / chemistry ; Stromal Cells / cytology ; Stromal Cells / drug effects ; Stromal Cells / metabolism ; Time Factors Substance Nomenclature: 0 (Drugs, Chinese Herbal) ; 0 (Flavonoids) ; 0 (Saponins) ; 0 (Triterpenes) ; 3A592W8XKE (astragaloside A) ; EC 3.1.3.1 (Alkaline Phosphatase) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20070301 Date Completed: 20071011 Latest Revision: 20181201 Update Code: 20240513

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