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The aim of this study was to determine the predictive and prognostic value of epidermal growth factor receptor (EGFR) expression in rectal cancers treated with preoperative high-dose rate brachytherapy and in mismatch-repair (MMR)-proficient colorectal cancers (CRCs), respectively. We validate the use of receiver operating characteristic (ROC) curve analysis to select cutoff scores for EGFR overexpression for the end points studied. Immunohistochemistry (IHC) for EGFR was performed on 82 rectal tumour biopsies and 1197 MMR-proficient CRCs using a tissue microarray. Immunoreactivity was scored as the percentage of positive tumour cells by three pathologists and the inter-observer reliability was assessed. ROC curve-derived cutoffs were used to analyse the association of EGFR overexpression, tumour response and several clinicopathological features including survival. The scoring method was found to be reproducible in rectal cancer biopsies and CRCs. The selected cutoff scores from ROC curve analysis for each clinicopathological feature were highly consistent among pathologists. EGFR overexpression was associated with response to radiotherapy (P-value <0.001) and with worse survival time (P-value <0.001). In multivariate analysis, EGFR overexpression was independently associated with adverse prognosis (P-value <0.001). Epidermal growth factor receptor is a predictive marker of response to preoperative radiotherapy and an independent adverse prognostic factor CRC.

Titel:	A simple and reproducible scoring system for EGFR in colorectal cancer: application to prognosis and prediction of response to preoperative brachytherapy.
Autor/in / Beteiligte Person:	Zlobec, I ; Vuong, T ; Hayashi, S ; Haegert, D ; Tornillo, L ; Terracciano, L ; Lugli, A ; Jass, J
Link:	Zum Volltext
Zeitschrift:	British journal of cancer, Jg. 96 (2007-03-12), Heft 5, S. 793
Veröffentlichung:	2002- : London : Nature Publishing Group on behalf of Cancer Research UK ; <i>Original Publication</i>: London, Lewis., 2007
Medientyp:	academicJournal
ISSN:	0007-0920 (print)
DOI:	10.1038/sj.bjc.6603619
Schlagwort:	Adenocarcinoma pathology Adenocarcinoma radiotherapy Biomarkers, Tumor analysis Colorectal Neoplasms pathology Colorectal Neoplasms radiotherapy Humans Immunohistochemistry Neoadjuvant Therapy Predictive Value of Tests Prognosis Reproducibility of Results Treatment Outcome Adenocarcinoma metabolism Brachytherapy Colorectal Neoplasms metabolism ErbB Receptors metabolism ROC Curve Tissue Array Analysis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Validation Study Language: English [Br J Cancer] 2007 Mar 12; Vol. 96 (5), pp. 793-800. <i>Date of Electronic Publication: </i>2007 Feb 20. MeSH Terms: Brachytherapy* ; ROC Curve* ; Tissue Array Analysis* ; Adenocarcinoma / metabolism ; Colorectal Neoplasms / metabolism ; ErbB Receptors / *metabolism ; Adenocarcinoma / pathology ; Adenocarcinoma / radiotherapy ; Biomarkers, Tumor / analysis ; Colorectal Neoplasms / pathology ; Colorectal Neoplasms / radiotherapy ; Humans ; Immunohistochemistry ; Neoadjuvant Therapy ; Predictive Value of Tests ; Prognosis ; Reproducibility of Results ; Treatment Outcome References: Cancer Res. 1991 Mar 1;51(5):1452-9. (PMID: 1847663) ; Br J Cancer. 1992 Feb;65(2):189-92. (PMID: 1739615) ; Cancer. 1993 Apr 15;71(8):2454-60. (PMID: 8095852) ; Anticancer Res. 1997 Sep-Oct;17(5B):3883-8. (PMID: 9427797) ; Clin Cancer Res. 1995 Jan;1(1):19-31. (PMID: 9815883) ; Am J Pathol. 1999 Apr;154(4):981-6. (PMID: 10233835) ; J Biol Chem. 2000 Mar 24;275(12):8641-9. (PMID: 10722704) ; J Natl Cancer Inst. 2000 Aug 2;92(15):1252-9. (PMID: 10922410) ; Nat Rev Mol Cell Biol. 2001 Feb;2(2):127-37. (PMID: 11252954) ; J Pathol. 2001 Jul;194(3):349-57. (PMID: 11439368) ; Clin Exp Metastasis. 2000;18(5):423-8. (PMID: 11467775) ; J Natl Cancer Inst. 2001 Aug 1;93(15):1141-6. (PMID: 11481385) ; Cancer. 2001 Sep 1;92(5):1331-46. (PMID: 11571750) ; Am J Pathol. 2001 Dec;159(6):2249-56. (PMID: 11733374) ; Front Biosci. 2002 Feb 1;7:d376-89. (PMID: 11815285) ; Surg Oncol. 2004 Aug-Nov;13(2-3):83-92. (PMID: 15572090) ; Ann Oncol. 2005 Jan;16(1):102-8. (PMID: 15598946) ; Tumour Biol. 2004 Sep-Dec;25(5-6):228-34. (PMID: 15627885) ; Ann Oncol. 2005 Feb;16(2):189-94. (PMID: 15668269) ; Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):260-6. (PMID: 15850931) ; J Natl Cancer Inst. 2005 Jun 15;97(12):927-30. (PMID: 15956654) ; Gastroenterology. 2005 Aug;129(2):415-21. (PMID: 16083698) ; BMC Cancer. 2005;5:62. (PMID: 15967033) ; Ann Oncol. 2005 Sep;16(9):1503-7. (PMID: 15980160) ; J Clin Oncol. 2005 Aug 20;23(24):5560-7. (PMID: 16110017) ; Jpn J Clin Oncol. 1995 Dec;25(6):240-9. (PMID: 8523820) ; Cancer. 1996 Jul 15;78(2):202-10. (PMID: 8673993) ; Cancer Metastasis Rev. 1995 Dec;14(4):323-38. (PMID: 8821093) ; Brachytherapy. 2005;4(3):230-5. (PMID: 16182224) ; Bull Cancer. 2005 Aug;92(Spec no):S5-11. (PMID: 16387663) ; Int J Radiat Oncol Biol Phys. 2006 Mar 1;64(3):765-70. (PMID: 16257129) ; Clin Cancer Res. 2006 Feb 15;12(4):1175-83. (PMID: 16489071) ; Cancer. 2006 Apr 1;106(7):1507-13. (PMID: 16518812) ; Int J Radiat Oncol Biol Phys. 2006 May 1;65(1):246-54. (PMID: 16618579) ; Ann Surg Oncol. 2006 Jun;13(6):823-35. (PMID: 16614884) ; Ann Oncol. 2006 Jun;17(6):981-5. (PMID: 16524970) ; Histopathology. 2006 Jun;48(7):787-94. (PMID: 16722926) ; Hum Pathol. 2006 Aug;37(8):1022-31. (PMID: 16867865) ; Oncology. 2006;70(3):161-7. (PMID: 16675911) ; Mod Pathol. 2006 Sep;19(9):1236-42. (PMID: 16741523) ; Virchows Arch. 2006 Sep;449(3):281-7. (PMID: 16865406) ; Histopathology. 2006 Oct;49(4):406-10. (PMID: 16978204) ; Mod Pathol. 2006 Oct;19(10):1302-9. (PMID: 16763611) ; Histopathology. 2007 Mar;50(4):453-64. (PMID: 17448021) ; J Clin Pathol. 2007 May;60(5):534-9. (PMID: 16816167) ; J Clin Pathol. 2007 Oct;60(10):1112-6. (PMID: 17182662) ; Psychol Bull. 1979 Mar;86(2):420-8. (PMID: 18839484) ; J Clin Oncol. 2002 May 1;20(9):2217-9. (PMID: 11980990) ; Clin Cancer Res. 2002 May;8(5):994-1003. (PMID: 12006511) ; Dis Colon Rectum. 2002 Nov;45(11):1486-93; discussion 1493-5. (PMID: 12432296) ; Eur J Cancer. 2002 Nov;38(17):2258-64. (PMID: 12441262) ; Cancer. 2003 Feb 15;97(4):960-8. (PMID: 12569594) ; Nat Rev Drug Discov. 2003 Dec;2(12):962-72. (PMID: 14654795) ; Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):561-6. (PMID: 14751528) ; Mod Pathol. 2004 May;17(5):579-87. (PMID: 15073595) ; Clin Cancer Res. 2004 May 1;10(9):3069-75. (PMID: 15131045) ; Int J Radiat Oncol Biol Phys. 2004;59(2 Suppl):21-6. (PMID: 15142631) ; Appl Immunohistochem Mol Morphol. 2004 Mar;12(1):8-13. (PMID: 15163012) ; J Histochem Cytochem. 2004 Jul;52(7):893-901. (PMID: 15208356) ; N Engl J Med. 2004 Jul 22;351(4):337-45. (PMID: 15269313) ; Cancer Res. 1988 Jan 1;48(1):137-41. (PMID: 2446740) ; Cancer Lett. 1988 Dec 1;43(1-2):139-43. (PMID: 3264518) ; Crit Rev Diagn Imaging. 1989;29(3):307-35. (PMID: 2667567) ; Cancer. 1990 Apr 1;65(7):1619-25. (PMID: 2311071) ; Anticancer Res. 1990 May-Jun;10(3):605-11. (PMID: 2195985) ; Cancer Res. 1990 Nov 1;50(21):7077-80. (PMID: 2208175) ; Br J Cancer. 1991 Jan;63(1):146-50. (PMID: 1846551) Substance Nomenclature: 0 (Biomarkers, Tumor) ; EC 2.7.10.1 (ErbB Receptors) Entry Date(s): Date Created: 20070222 Date Completed: 20070504 Latest Revision: 20191210 Update Code: 20231215 PubMed Central ID: PMC2360062

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A simple and reproducible scoring system for EGFR in colorectal cancer: application to prognosis and prediction of response to preoperative brachytherapy.