Valproic acid-induced hepatopathy: nine new fatalities in Germany from 1994 to 2003.
In: Epilepsia, Jg. 47 (2006-12-01), Heft 12, S. 2027-31
Online
academicJournal
Zugriff:
Purpose: Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies. We provide an update on hepatotoxic side effects in Germany between 1994 and 2003.
Methods: We mailed a questionnaire to all members of the German Section of the International League Against Epilepsy, asking for VPA-induced side effects, especially severe side effects such as hepatopathy.
Results: As a result of our questionnaire, we found 31 cases of reversible hepatotoxicity and nine cases of lethal hepatopathies in Germany from 1994 to 2003.
Conclusions: The outcome of patients with severe hepatotoxicity is better than that in the past. The risk of a VPA-induced hepatopathy is not limited to patients younger than 2 years, receiving polytherapy, or patients with congenital or acquired metabolic diseases.
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Valproic acid-induced hepatopathy: nine new fatalities in Germany from 1994 to 2003.
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| Autor/in / Beteiligte Person: | Koenig, SA ; Buesing, D ; Longin, E ; Oehring, R ; Häussermann, P ; Kluger, G ; Lindmayer, F ; Hanusch, R ; Degen, I ; Kuhn, H ; Samii, K ; Jungck, A ; Brückner, R ; Seitz, R ; Boxtermann, W ; Weber, Y ; Knapp, R ; Richard, HH ; Weidner, B ; Kasper, JM ; Haensch, CA ; Fitzek, S ; Hartmann, M ; Borusiak, P ; Müller-Deile, A ; Degenhardt, V ; Korenke, GC ; Hoppen, T ; Specht, U ; Gerstner, T |
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| Zeitschrift: | Epilepsia, Jg. 47 (2006-12-01), Heft 12, S. 2027-31 |
| Veröffentlichung: | Malden, MA : Blackwell Science ; <i>Original Publication</i>: Copenhagen : Munskgaard, 2006 |
| Medientyp: | academicJournal |
| ISSN: | 0013-9580 (print) |
| DOI: | 10.1111/j.1528-1167.2006.00846.x |
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