Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria.
In: AIDS (London, England), Jg. 20 (2006-01-09), Heft 2, S. 275-80
Online
academicJournal
Zugriff:
Objective: Since the primary hematological complication in both pediatric HIV-1 and malaria is anemia, co-infection with these pathogens may promote life-threatening severe malarial anemia (SMA). The primary objective of the study was to determine if HIV-1 exposure [HIV-1(exp)] and/or HIV-1 infection [HIV-1(+)] increased the prevalence of SMA in children with acute malaria.
Methods: Upon enrollment, a complete hematological and clinical evaluation was performed on all children. Malaria parasitemia was determined and children with acute P. falciparum malaria were evaluated for HIV-1 exposure and infection by two rapid serological antibody tests and HIV-1 DNA PCR, respectively.
Results: Relative to HIV-1(-) group (n = 194), the HIV-1(exp) (n = 100) and HIV-1(+) (n = 23) groups had lower hemoglobin concentrations (P < 0.001 and P < 0.001, respectively), while parasitemia and HDP were equivalent between the three groups. Multivariate analyses demonstrated that the risk of SMA was elevated in HIV-1(exp) children (odds ratio, 2.17; 95% confidence interval, 1.25-3.78; P < 0.01) and HIV-1(+) children (odds ratio, 8.71; 95% confidence interval, 3.37-22.51; P < 0.0001). The multivariate model further revealed that HIV-1 exposure or infection were not significantly associated with HDP.
Conclusions: Results presented here demonstrate that both HIV-1 exposure and HIV-1 infection are associated with increased prevalence of SMA during acute P. falciparum infection, independent of parasite density.
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Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria.
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Autor/in / Beteiligte Person: | Otieno, RO ; Ouma, C ; Ong'echa, JM ; Keller, CC ; Were, T ; Waindi, EN ; Michaels, MG ; Day, RD ; Vulule, JM ; Perkins, DJ |
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Zeitschrift: | AIDS (London, England), Jg. 20 (2006-01-09), Heft 2, S. 275-80 |
Veröffentlichung: | 1998- : London, England : Lippincott Williams & Wilkins ; <i>Original Publication</i>: London : Gower Academic Journals, c1987-, 2006 |
Medientyp: | academicJournal |
ISSN: | 0269-9370 (print) |
DOI: | 10.1097/01.aids.0000200533.56490.b7 |
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