Brain penetration of the novel free radical trapping neuroprotectant NXY-059 in rats subjected to permanent focal ischemia.
In: Brain research, Jg. 1072 (2006-02-09), Heft 1, S. 224
Online
academicJournal
Zugriff:
The penetration of the free radical trapping neuroprotectant NXY-059 into the brain has been examined in rats subjected to permanent middle cerebral artery occlusion (pMCAO). NXY-059 (125 mg/kg bolus followed by 125 mg/kg/h) was infused for 4 h 45 min starting 15 min after right pMCAO or sham operation. At 5 h, there was a similar plasma total NXY-059 concentration (micromol/L) in both groups [sham: 623 +/- 44 (6); pMCAO: 605 +/- 43 (5)] and a similar drug concentration (nmol/g) in the right cortex [sham: 6.92 +/- 1.05 (6); pMCAO: 6.14 +/- 2.18 (6)]. A subsequent experiment in normal rats, infusing NXY-059 at both a similar and higher concentration (252 mg/kg bolus and 252 mg/kg/h), demonstrated that the concentration of NXY-059 in cortex increased linearly with respect to the plasma concentration. These data demonstrate that NXY-059 does penetrate brain tissue in control animals and ischemic tissue of animals subjected to pMCAO.
| Titel: |
Brain penetration of the novel free radical trapping neuroprotectant NXY-059 in rats subjected to permanent focal ischemia.
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| Autor/in / Beteiligte Person: | Green, AR ; Lanbeck-Vallén, K ; Ashwood, T ; Lundquist, S ; Lindström Böö, E ; Jonasson, H ; Campbell, M |
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| Zeitschrift: | Brain research, Jg. 1072 (2006-02-09), Heft 1, S. 224 |
| Veröffentlichung: | Amsterdam Elsevier/North-Holland Biomedical Press., 2006 |
| Medientyp: | academicJournal |
| ISSN: | 0006-8993 (print) |
| DOI: | 10.1016/j.brainres.2005.12.035 |
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