Relation between XbA1 apolipoprotein B gene polymorphism and cardiovascular risk in a type 2 diabetic cohort.
In: Atherosclerosis, Jg. 175 (2004-07-01), Heft 1, S. 177
Online
academicJournal
Zugriff:
Aim: To evaluate in a prospective study the association of XbA1 apolipoprotein B (apoB) gene polymorphism with lipid parameters and cardiovascular (CV) events in a type 2 diabetic cohort.
Methods and Results: A cohort of 212 type 2 diabetic patients, free of any cardiovascular complication, was studied. Cardiovascular events were registered for all the patients for 5 years. XbA1 apolipoprotein B gene polymorphism was analysed by PCR-RFLP method. A mild increase in HbA1c was found in X+X+ carriers (P = 0.014). Despite this lower glycemic control, there were no differences between genotype subgroups for lipid parameters except for apoB, significantly higher in X+X+ than in X-X- subjects. In univariate analysis, the cardiovascular events rate was higher in X-X- but did not reach statistical significance (P =0.07). In stepwise multivariate regression analysis, cardiovascular events risk was significantly higher in X- carriers (P = 0.014) and also in smokers, microalbuminuric and older patients.
Conclusions: We report for the first time in a prospective study the association of XbA1 apolipoprotein B gene polymorphism and cardiovascular events in a diabetic population. The mechanism underlying the excess of cardiovascular risk in X- carriers, despite a better metabolic profile, is likely to involve a linkage disequilibrium between apolipoprotein B gene locus and another gene locus related to cardiovascular risk.
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Relation between XbA1 apolipoprotein B gene polymorphism and cardiovascular risk in a type 2 diabetic cohort.
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Autor/in / Beteiligte Person: | Bernard, S ; Charrière, S ; Charcosset, M ; Berthezène, F ; Moulin, P ; Sassolas, A |
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Zeitschrift: | Atherosclerosis, Jg. 175 (2004-07-01), Heft 1, S. 177 |
Veröffentlichung: | Limerick : Elsevier ; <i>Original Publication</i>: Amsterdam, Elsevier., 2004 |
Medientyp: | academicJournal |
ISSN: | 0021-9150 (print) |
DOI: | 10.1016/j.atherosclerosis.2004.03.017 |
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