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Background: Parasite-specific IgE levels correlate with human resistance to reinfection with Schistosoma spp. after chemotherapy. Although the role of eosinophils in schistosomiasis has been the focus of a great deal of important research, the involvement of other Fcepsilon receptor-bearing cells, such as mast cells and basophils, has not been investigated in relation to human immunity to schistosomes. Chemotherapy with praziquantel (PZQ) kills schistosomes living in an in vivo blood environment rich in IgE, eosinophils and basophils. This releases parasite Ags that have the potential to cross-link cell-bound IgE. However, systemic hypersensitivity reactions are not induced by treatment. Here, we describe the effects of schistosomiasis, and its treatment, on human basophil function by following changes in total cellular histamine and in vitro histamine-release induced by schistosome Ags or anti-IgE, in blood samples from infected Ugandan fishermen, who are continuously exposed to S. mansoni infection, before and 1-day and 21-days after PZQ treatment.

Results: There was a significant increase in the total cellular histamine in blood samples at 1-day post-treatment, followed by a very significant further increase by 21-days post-treatment. In vitro histamine-release induced by S. mansoni egg (SEA) or worm (SWA) Ags or anti-IgE antibody, was significantly reduced 1-day post-treatment. The degree of this reduction correlated with pre-treatment infection intensity. Twenty-1-days post-treatment, SEA-induced histamine-release was still significantly lower than at pretreatment. Histamine-release was not correlated to plasma concentrations of total or parasite-specific IgE, nor to specific IgG4 plasma concentrations.

Conclusion: The biology of human blood basophils is modulated by S. mansoni infection and praziquantel treatment. Infection intensity-dependent suppression of basophil histamine-release, histamine-dependent resistance to infection, and similarities with allergen desensitisation are discussed as possible explanations of these observations.

Titel:	Changes in IgE- and antigen-dependent histamine-release in peripheral blood of Schistosoma mansoni-infected Ugandan fishermen after treatment with praziquantel.
Autor/in / Beteiligte Person:	Satti, MZ ; Cahen, P ; Skov, PS ; Joseph, S ; Jones, FM ; Fitzsimmons, C ; Hoffmann, KF ; Reimert, C ; Kariuki, HC ; Kazibwe, F ; Mwatha, JK ; Kimani, G ; Vennervald, BJ ; Ouma, JH ; Kabatereine, NB ; Dunne, DW
Link:	Zum Volltext
Zeitschrift:	BMC immunology, Jg. 5 (2004-04-21), S. 6
Veröffentlichung:	London : BioMed Central, [2000-, 2004
Medientyp:	academicJournal
ISSN:	1471-2172 (electronic)
DOI:	10.1186/1471-2172-5-6
Schlagwort:	Animals Antibodies, Anti-Idiotypic blood Cohort Studies Enzyme-Linked Immunosorbent Assay Fisheries Histamine blood Histamine Release immunology Humans Male Schistosoma mansoni drug effects Schistosoma mansoni immunology Schistosomiasis mansoni blood Schistosomiasis mansoni immunology Spectrometry, Fluorescence Time Factors Uganda Anthelmintics therapeutic use Antigens, Helminth blood Histamine Release drug effects Immunoglobulin E blood Praziquantel therapeutic use Schistosomiasis mansoni drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Language: English [BMC Immunol] 2004 Apr 21; Vol. 5, pp. 6. <i>Date of Electronic Publication: </i>2004 Apr 21. MeSH Terms: Anthelmintics / therapeutic use ; Antigens, Helminth / blood ; Histamine Release / drug effects ; Immunoglobulin E / blood ; Praziquantel / therapeutic use ; Schistosomiasis mansoni / drug therapy ; Animals ; Antibodies, Anti-Idiotypic / blood ; Cohort Studies ; Enzyme-Linked Immunosorbent Assay ; Fisheries ; Histamine / blood ; Histamine Release / immunology ; Humans ; Male ; Schistosoma mansoni / drug effects ; Schistosoma mansoni / immunology ; Schistosomiasis mansoni / blood ; Schistosomiasis mansoni / immunology ; Spectrometry, Fluorescence ; Time Factors ; Uganda References: Biomed Pharmacother. 1985;39(1):32-5. (PMID: 2411308) ; Trop Med Int Health. 1996 Oct;1(5):655-66. (PMID: 8911450) ; Trans R Soc Trop Med Hyg. 1987;81(6):938-46. (PMID: 3140435) ; Am J Trop Med Hyg. 1989 Mar;40(3):268-72. (PMID: 2494898) ; Trans R Soc Trop Med Hyg. 1989 May-Jun;83(3):368-72. (PMID: 2515625) ; Nature. 1991 Jan 17;349(6306):243-5. (PMID: 1898985) ; Braz J Med Biol Res. 1990;23(3-4):275-81. (PMID: 2128820) ; Eur J Immunol. 1991 Nov;21(11):2679-86. (PMID: 1936116) ; Allergy. 1991 Nov;46(8):626-31. (PMID: 1724117) ; Eur J Immunol. 1992 Jun;22(6):1483-94. (PMID: 1601036) ; Infect Immun. 1993 Dec;61(12):4984-93. (PMID: 8225573) ; Mem Inst Oswaldo Cruz. 1992;87 Suppl 4:167-70. (PMID: 1343889) ; Agents Actions. 1994 Jun;41 Spec No:C24-5. (PMID: 7526647) ; Parasitology. 1997 Apr;114 ( Pt 4):383-93. (PMID: 9107025) ; Trans R Soc Trop Med Hyg. 1997 Sep-Oct;91(5):606-8. (PMID: 9463682) ; J Infect Dis. 1998 Aug;178(2):512-9. (PMID: 9697734) ; Clin Exp Allergy. 1998 Oct;28(10):1292-8. (PMID: 9824397) ; Acta Trop. 1999 Jan 15;72(1):53-63. (PMID: 9924961) ; J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):326-32. (PMID: 9949326) ; Int Arch Allergy Immunol. 2000 Oct;123(2):145-8. (PMID: 11060486) ; Clin Exp Allergy. 2000 Nov;30(11):1583-9. (PMID: 11069567) ; Lancet. 2000 Nov 18;356(9243):1723-7. (PMID: 11095260) ; Ann Allergy Asthma Immunol. 2001 Mar;86(3):337-42. (PMID: 11289336) ; Parasite Immunol. 2001 Aug;23(8):427-34. (PMID: 11489166) ; J Biol Chem. 2002 Aug 23;277(34):31207-13. (PMID: 12050167) ; J Biol Chem. 2003 May 16;278(20):18384-92. (PMID: 12624091) ; Allergy. 2003 Oct;58(10):1037-43. (PMID: 14510723) ; Parasitology. 1965 Nov;55(4):695-700. (PMID: 4957633) ; Nature. 1971 Aug 27;232(5313):653-4. (PMID: 4999224) ; Rev Inst Med Trop Sao Paulo. 1972 Nov-Dec;14(6):397-400. (PMID: 4675644) ; Scand J Immunol. 1975;4(2):103-12. (PMID: 49918) ; Eur J Clin Pharmacol. 1978 Dec 1;14(4):281-91. (PMID: 729622) ; J Exp Med. 1980 Jul 1;152(1):41-53. (PMID: 7400756) ; J Allergy Clin Immunol. 1980 Oct;66(4):305-13. (PMID: 7419833) ; Cell. 1980 Nov;22(1 Pt 1):59-67. (PMID: 6159103) ; Trans R Soc Trop Med Hyg. 1981;75(1):54-71. (PMID: 6973849) ; Am J Trop Med Hyg. 1981 Nov;30(6):1228-37. (PMID: 6172989) ; Int Arch Allergy Appl Immunol. 1982;69(3):282-4. (PMID: 7129661) ; Clin Exp Immunol. 1983 Apr;52(1):144-52. (PMID: 6861371) ; Parasitology. 1996 Jan;112 ( Pt 1):47-58. (PMID: 8587801) ; Infect Immun. 1996 Oct;64(10):4042-6. (PMID: 8926066) ; J Immunol Methods. 1987 May 20;99(2):195-7. (PMID: 3584991) Grant Information: G7708609 United Kingdom MRC_ Medical Research Council Substance Nomenclature: 0 (Anthelmintics) ; 0 (Antibodies, Anti-Idiotypic) ; 0 (Antigens, Helminth) ; 0 (anti-IgE antibodies) ; 37341-29-0 (Immunoglobulin E) ; 6490C9U457 (Praziquantel) ; 820484N8I3 (Histamine) Entry Date(s): Date Created: 20040423 Date Completed: 20051107 Latest Revision: 20220129 Update Code: 20240513 PubMed Central ID: PMC419341

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Changes in IgE- and antigen-dependent histamine-release in peripheral blood of Schistosoma mansoni-infected Ugandan fishermen after treatment with praziquantel.