Effects on serum retinol of multi-micronutrient supplementation and multi-helminth chemotherapy: a randomised, controlled trial in Kenyan school children.
In: European journal of clinical nutrition, Jg. 56 (2002-07-01), Heft 7, S. 666
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Zugriff:
Objective: To assess the effects of multi-micronutrient supplementation and multi-helminth chemotherapy on serum retinol concentration, using schools as a health delivery system. STUDY AREA AND POPULATION: From 19 primary schools in Bondo District, western Kenya, 977 children between 9 and 18 y were included in the trial. The 644 (65.9%) children on whom baseline serum retinol was available were included in this study.
Design: A randomised, placebo-controlled, double-blind, two-by-two factorial trial on the effects of multi-micronutrient supplementation and multi-helminth chemotherapy on serum retinol after 8 months.
Intervention: Single treatment with albendazole (600 mg) and praziquantel (40 mg/kg of body weight) and daily multi-micronutrient supplementation with tablet containing 1000 microg vitamin A.
Results: Micronutrient supplementation (0.08 micromol/l, 95% CI 0.01, 0.14; P=0.025), but not treatment (0.03 micromol/l, 95% CI -0.04, 0.10; P=0.38), increased serum retinol. However, treatment did increase serum retinol in S. mansoni-infected (0.09, 95% CI 0.02, 0.16; P=0.009), but not in uninfected children (-0.07, 95% CI -0.18, 0.03; P=0.18; interaction, P=0.01). Similarly, reduction in egg output of S. mansoni, but none of the geohelminth, was a predictor, corresponding to a 0.008 micromol/l (95% CI 0.00002, 0.02; P=0.049) increase in serum retinol per 100 epg reduction. Interestingly, interactions were found between age and sex (P=0.046), and malaria parasitaemia and sickle cell phenotype (P=0.04).
Conclusion: Multi-micronutrient supplementation and reduction in S. mansoni egg output increased serum retinol, irrespective of initial serum retinol.
Sponsorship: The Danish International Development Assistance.
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Effects on serum retinol of multi-micronutrient supplementation and multi-helminth chemotherapy: a randomised, controlled trial in Kenyan school children.
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Autor/in / Beteiligte Person: | Mwaniki, D ; Omondi, B ; Muniu, E ; Thiong'o, F ; Ouma, J ; Magnussen, P ; Geissler, PW ; Michaelsen, KF ; Friis, H |
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Zeitschrift: | European journal of clinical nutrition, Jg. 56 (2002-07-01), Heft 7, S. 666 |
Veröffentlichung: | <2003->: London : Nature Publishing Group ; <i>Original Publication</i>: London : J. Libbey, c1988-, 2002 |
Medientyp: | academicJournal |
ISSN: | 0954-3007 (print) |
DOI: | 10.1038/sj.ejcn.1601376 |
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