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Apoptosis in T and B lymphocytes is a major element controlling the immune response. Activation induced cell death (AICD) in T cells is a main mechanism for maintaining peripheral tolerance and for limiting an ongoing immune response. AICD is initiated by antigen reengagement of the T cell receptor (TCR), and mediated through Fas/Fas ligand (FasL) interactions. VIP and PACAP are two multifunctional neuropeptides present in the lymphoid microenvironment that act primarily as anti-inflammatory agents. In this study we report on the role of VIP and PACAP on T cell AICD, and on the mechanisms involved. VIP and PACAP inhibit AICD in vivo and in vitro, in peripheral T cells and T cell hybridomas. The effect is dose dependent and is mediated through the specific receptors VPAC1 and VPAC2. The inhibition of AICD is achieved through reduction in FasL expression at protein and mRNA level. By affecting FasL expression, VIP and PACAP may play a physiological role in both the generation of memory T cells and the inhibition of FasL-mediated T cell cytotoxicity.

Titel:	VIP and PACAP inhibit activation induced apoptosis in T lymphocytes.
Autor/in / Beteiligte Person:	Delgado, M ; Ganea, D
Link:	Zum Volltext
Zeitschrift:	Annals of the New York Academy of Sciences, Jg. 921 (2000), S. 55-67
Veröffentlichung:	2006- : New York, NY : Malden, MA : New York Academy of Sciences ; Blackwell ; <i>Original Publication</i>: New York, The Academy., 2000
Medientyp:	academicJournal
ISSN:	0077-8923 (print)
DOI:	10.1111/j.1749-6632.2000.tb06951.x
Schlagwort:	Animals Base Sequence CD3 Complex metabolism DNA Primers genetics Fas Ligand Protein Hybridomas cytology Hybridomas drug effects Hybridomas immunology In Vitro Techniques Membrane Glycoproteins genetics Membrane Glycoproteins metabolism Mice Mice, Inbred BALB C Neuropeptides administration & dosage Pituitary Adenylate Cyclase-Activating Polypeptide RNA, Messenger genetics RNA, Messenger metabolism Receptors, Vasoactive Intestinal Peptide genetics Receptors, Vasoactive Intestinal Peptide metabolism Receptors, Vasoactive Intestinal Peptide, Type II Receptors, Vasoactive Intestinal Polypeptide, Type I T-Lymphocytes cytology Vasoactive Intestinal Peptide administration & dosage Apoptosis drug effects Lymphocyte Activation Neuropeptides pharmacology T-Lymphocytes drug effects T-Lymphocytes immunology Vasoactive Intestinal Peptide pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Ann N Y Acad Sci] 2000; Vol. 921, pp. 55-67. MeSH Terms: Lymphocyte Activation* ; Apoptosis / drug effects ; Neuropeptides / pharmacology ; T-Lymphocytes / drug effects ; T-Lymphocytes / immunology ; Vasoactive Intestinal Peptide / *pharmacology ; Animals ; Base Sequence ; CD3 Complex / metabolism ; DNA Primers / genetics ; Fas Ligand Protein ; Hybridomas / cytology ; Hybridomas / drug effects ; Hybridomas / immunology ; In Vitro Techniques ; Membrane Glycoproteins / genetics ; Membrane Glycoproteins / metabolism ; Mice ; Mice, Inbred BALB C ; Neuropeptides / administration & dosage ; Pituitary Adenylate Cyclase-Activating Polypeptide ; RNA, Messenger / genetics ; RNA, Messenger / metabolism ; Receptors, Vasoactive Intestinal Peptide / genetics ; Receptors, Vasoactive Intestinal Peptide / metabolism ; Receptors, Vasoactive Intestinal Peptide, Type II ; Receptors, Vasoactive Intestinal Polypeptide, Type I ; T-Lymphocytes / cytology ; Vasoactive Intestinal Peptide / administration & dosage Substance Nomenclature: 0 (Adcyap1 protein, mouse) ; 0 (CD3 Complex) ; 0 (DNA Primers) ; 0 (Fas Ligand Protein) ; 0 (Fasl protein, mouse) ; 0 (Membrane Glycoproteins) ; 0 (Neuropeptides) ; 0 (Pituitary Adenylate Cyclase-Activating Polypeptide) ; 0 (RNA, Messenger) ; 0 (Receptors, Vasoactive Intestinal Peptide) ; 0 (Receptors, Vasoactive Intestinal Peptide, Type II) ; 0 (Receptors, Vasoactive Intestinal Polypeptide, Type I) ; 37221-79-7 (Vasoactive Intestinal Peptide) Entry Date(s): Date Created: 20010224 Date Completed: 20010201 Latest Revision: 20190616 Update Code: 20240513

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VIP and PACAP inhibit activation induced apoptosis in T lymphocytes.