Cognitive dysfunction induced by phenytoin and valproate in rats: effect of nitric oxide.

Pandhi, P ; Balakrishnan, S

In: Indian journal of physiology and pharmacology, Jg. 43 (1999-07-01), Heft 3, S. 378

academicJournal

Phenytoin (PHT) and Valproate (VPA) are known to induce cognitive dysfunction, in terms of long term memory loss. Nitric oxide (NO) on the other hand is said to help in long term potentiation and hence enhance memory. The effects of nitric oxide donor L-arginine (L-Arg) and nitric oxide synthase inhibitor N-W-L-Nitroarginine (L-NOARG) were studied on the cognitive dysfunction, induced by PHT and VPA in normal healthy rats, using the step-through passive avoidance test (PAT). It was observed that combining L-Arg with PHT significantly enhanced long term memory while, combining PHT with L-NOARG decreased it, as compared to PHT alone. When combined with VPA, L-Arg and L-NOARG increased the retention latency as compared to PVA alone but this was not statistically significant. We conclude that the No donor L-Arg is able to increase the difference in LTE in acquisition and retention trials with both PHT and VPA, but with VPA the increase is not statistically significant.

Titel:	Cognitive dysfunction induced by phenytoin and valproate in rats: effect of nitric oxide.
Autor/in / Beteiligte Person:	Pandhi, P ; Balakrishnan, S
Zeitschrift:	Indian journal of physiology and pharmacology, Jg. 43 (1999-07-01), Heft 3, S. 378
Veröffentlichung:	New Delhi : Dept. Of Physiology, All-India Institute Of Medical Sciences Etc, 1999
Medientyp:	academicJournal
ISSN:	0019-5499 (print)
Schlagwort:	Animals Arginine pharmacology Cognition Disorders psychology Enzyme Inhibitors pharmacology Female Male Memory drug effects Nitric Oxide Donors pharmacology Nitric Oxide Synthase antagonists & inhibitors Nitroarginine pharmacology Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate drug effects Anticonvulsants toxicity Cognition Disorders chemically induced Cognition Disorders physiopathology Nitric Oxide physiology Phenytoin toxicity Valproic Acid toxicity
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Indian J Physiol Pharmacol] 1999 Jul; Vol. 43 (3), pp. 378-82. MeSH Terms: Anticonvulsants / toxicity ; Cognition Disorders / chemically induced ; Cognition Disorders / physiopathology ; Nitric Oxide / physiology ; Phenytoin / toxicity ; Valproic Acid / toxicity ; Animals ; Arginine / pharmacology ; Cognition Disorders / psychology ; Enzyme Inhibitors / pharmacology ; Female ; Male ; Memory / drug effects ; Nitric Oxide Donors / pharmacology ; Nitric Oxide Synthase / antagonists & inhibitors ; Nitroarginine / pharmacology ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate / drug effects Substance Nomenclature: 0 (Anticonvulsants) ; 0 (Enzyme Inhibitors) ; 0 (Nitric Oxide Donors) ; 0 (Receptors, N-Methyl-D-Aspartate) ; 2149-70-4 (Nitroarginine) ; 31C4KY9ESH (Nitric Oxide) ; 614OI1Z5WI (Valproic Acid) ; 6158TKW0C5 (Phenytoin) ; 94ZLA3W45F (Arginine) ; EC 1.14.13.39 (Nitric Oxide Synthase) Entry Date(s): Date Created: 20000425 Date Completed: 20000515 Latest Revision: 20131121 Update Code: 20231215

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