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The gene encoding the mouse vasoactive intestinal polypeptide type 1 (VPAC1) receptor was cloned, and its structural organization was determined. The gene (Vipr1) is more than 16 kb in length and is divided into 13 exons. The 5'-flanking region is highly GC-rich and lacks an apparent TATA box, but contains a CCAAT box, three potential Sp1-binding sites, and two potential AP-2-binding sites. Promoter analysis of the 5'-flanking region of Vipr1 using a luciferase gene reporter system revealed that the isolated 5'-flanking region has functional promoter activity. The mouse Vipr1 gene is encoded by a single gene, which was mapped to the distal region of mouse chromosome 9. This region is syntenic with human chromosome 3p, where the human VPAC1 receptor gene has been mapped.

Titel:	Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC1) receptor.
Autor/in / Beteiligte Person:	Hashimoto, H ; Nishino, A ; Shintani, N ; Hagihara, N ; Copeland, NG ; Jenkins, NA ; Yamamoto, K ; Matsuda, T ; Ishihara, T ; Nagata, S ; Baba, A
Link:	Zum Volltext
Zeitschrift:	Genomics, Jg. 58 (1999-05-15), Heft 1, S. 90-3
Veröffentlichung:	San Diego : Academic Press, [c1987-, 1999
Medientyp:	academicJournal
ISSN:	0888-7543 (print)
DOI:	10.1006/geno.1999.5805
Schlagwort:	Animals Base Sequence Binding Sites Chromosome Mapping Chromosomes genetics Colforsin pharmacology DNA chemistry DNA genetics Exons Gene Expression Regulation drug effects Introns Luciferases genetics Luciferases metabolism Mice Mice, Inbred C57BL Mice, Inbred Strains Molecular Sequence Data Muridae PC12 Cells Promoter Regions, Genetic genetics Rats Receptors, Vasoactive Intestinal Polypeptide, Type I Recombinant Fusion Proteins genetics Recombinant Fusion Proteins metabolism Sequence Analysis, DNA Tetradecanoylphorbol Acetate pharmacology Transcription, Genetic Genes genetics Receptors, Vasoactive Intestinal Peptide genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Language: English [Genomics] 1999 May 15; Vol. 58 (1), pp. 90-3. MeSH Terms: Genes / genetics ; Receptors, Vasoactive Intestinal Peptide / genetics ; Animals ; Base Sequence ; Binding Sites ; Chromosome Mapping ; Chromosomes / genetics ; Colforsin / pharmacology ; DNA / chemistry ; DNA / genetics ; Exons ; Gene Expression Regulation / drug effects ; Introns ; Luciferases / genetics ; Luciferases / metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Molecular Sequence Data ; Muridae ; PC12 Cells ; Promoter Regions, Genetic / genetics ; Rats ; Receptors, Vasoactive Intestinal Polypeptide, Type I ; Recombinant Fusion Proteins / genetics ; Recombinant Fusion Proteins / metabolism ; Sequence Analysis, DNA ; Tetradecanoylphorbol Acetate / pharmacology ; Transcription, Genetic Molecular Sequence: GENBANK AB022848; AB022849; AB022850; AB022851; AB022852; AB022853; AB022854; AB022855; AB022856; AB022857; AB022858; AB022859; AB022860 Substance Nomenclature: 0 (Receptors, Vasoactive Intestinal Peptide) ; 0 (Receptors, Vasoactive Intestinal Polypeptide, Type I) ; 0 (Recombinant Fusion Proteins) ; 1F7A44V6OU (Colforsin) ; 9007-49-2 (DNA) ; EC 1.13.12.- (Luciferases) ; NI40JAQ945 (Tetradecanoylphorbol Acetate) Entry Date(s): Date Created: 19990520 Date Completed: 19990706 Latest Revision: 20131121 Update Code: 20240513

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Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC1) receptor.