An Approach to Model the Active Site of Peptidglycine-α-hydroxylating monooxygenase (PHM).
In: Zeitschrift für Anorganische und Allgemeine Chemie, Jg. 639 (2013-07-01), Heft 8/9, S. 1504-1511
Online
academicJournal
Zugriff:
The copper(I) and copper(II) complexes [Cu((TMGet)2NetSEt)]BPh4 ( 1·BPh4) and [Cu((TMGet)2NetSEt)Cl]Cl ( 2·Cl) with (TMGet)2NetSEt = ((Me2N)2C=NCH2CH2)2NCH2CH2SEt were synthesized and structurally characterized as a model system for the copper enzyme PHM, a monooxygenase involved in the activation of peptide hormones and neuropeptides. The reaction of the copper(I) complex 1·BPh4 with dioxygen has been studied using low temperature stopped-flow methods. However, in contrast to PHM no formation of an end-on copper superoxido complex could be observed. Instead an equilibrium between a bis-μ-oxo and a side-on peroxide complex was detected spectroscopically. [ABSTRACT FROM AUTHOR]
Titel: |
An Approach to Model the Active Site of Peptidglycine-α-hydroxylating monooxygenase (PHM).
|
---|---|
Autor/in / Beteiligte Person: | Hoppe, Tobias ; Josephs, Patrick ; Kempf, Natascha ; Wölper, Christoph ; Schindler, Siegfried ; Neuba, Adam ; Henkel, Gerald |
Link: | |
Zeitschrift: | Zeitschrift für Anorganische und Allgemeine Chemie, Jg. 639 (2013-07-01), Heft 8/9, S. 1504-1511 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 0044-2313 (print) |
DOI: | 10.1002/zaac.201300066 |
Schlagwort: |
|
Sonstiges: |
|