The effects of prenatal exposure to valproic acid on the initial development of serotonergic neurons
In: International Journal of Developmental Neuroscience, Jg. 31 (2013-05-01), Heft 3, S. 202-208
Online
academicJournal
Zugriff:
Abstract: In utero exposure to valproic acid (VPA) may cause symptoms related to autism spectrum disorder (ASD). An abnormal serotonergic (5-HT) system has been implicated in the etiology of ASD. In the present study, we have examined the expression and distribution of two early inducers of 5-HT neurons in rat embryos, to elucidate the prenatal development of 5-HT neurons after VPA exposure at embryonic day (E) 9.5. Whole-embryo in situ hybridization at E11.5 showed that the expression of sonic hedgehog, one of the early inducers of 5-HT neurons, was reduced around the isthmus in the VPA-exposed group. Furthermore, whole-mount immunohistochemistry of the hindbrain and quantitative analysis of 5-HT neurons in the rostral raphe nucleus (rRN) revealed that neuronal distribution in the caudal part of the rRN was narrower at E15.5 in the VPA-exposed group than in controls. Thus, the early development of 5-HT neurons was altered after VPA exposure in utero. The observed prenatal alteration may be significant in the etiology of autism. [Copyright &y& Elsevier]
| Titel: |
The effects of prenatal exposure to valproic acid on the initial development of serotonergic neurons
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| Autor/in / Beteiligte Person: | Oyabu, Akiko ; Narita, Masaaki ; Tashiro, Yasura |
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| Zeitschrift: | International Journal of Developmental Neuroscience, Jg. 31 (2013-05-01), Heft 3, S. 202-208 |
| Veröffentlichung: | 2013 |
| Medientyp: | academicJournal |
| ISSN: | 0736-5748 (print) |
| DOI: | 10.1016/j.ijdevneu.2013.01.006 |
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