Somatosensory evoked potentials in epileptic children treated with carbamazepine or valproate in monotherapy - a preliminary study.
In: Advances in Medical Sciences (De Gruyter Open), Jg. 55 (2010-12-01), Heft 2, S. 212-215
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Zugriff:
Purpose: Data from the literature suggest that long-term therapy with various antiepileptic drugs can be responsible for the functional disturbances within the nervous system e.g. peripheral neuropathy and encephalopathy. Useful and non-invasive instruments for evaluation of even subclinical nerve conduction abnormalities in somatosensory tracts are somatosensory evoked potentials (SEPs). The aim of this study was to assess the potentially drug-induced abnormalities in the SEP parameters in epileptic children, treated chronically in monotherapy with one of the two most often used antiepileptic drugs: valproate (VPA) or carbamazepine (CBZ).Materials and Methods: SEP from left median nerve stimulation were recorded in twenty children with idiopathic/cryptogenic epilepsy treated in monotherapy with CBZ (9 patients) or VPA (11 patients). The mean age of the patients was 13.4 ± 2.9 years (range 7-17 years). The plasma concentrations of the drugs were consistently within therapeutic range. The mean duration of treatment was eight months. The control group consisted of twenty-four age-matched children with tension type headache. The latencies of the components: N9, N13, N20, P25 and the peripheral conduction time (PCT) and central conduction time (CCT) were analyzed.Results: No significant differences in all analyzed SEP parameters between the epileptic and control children were found.Conclusions: Our results indicate that during the first 8 months from the beginning of antiepileptic treatment in children, monotherapy with VPA or CBZ does not induce nerve conduction disturbances within both the peripheral- and the central part of the somatosensory tracts, detected in SEP examination. [ABSTRACT FROM AUTHOR]
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Somatosensory evoked potentials in epileptic children treated with carbamazepine or valproate in monotherapy - a preliminary study.
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Autor/in / Beteiligte Person: | Sendrowski, K. ; Sobaniec, W. ; Bockowski, L. ; Kułak, W. ; Śmigielska-Kuzia, J. |
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Zeitschrift: | Advances in Medical Sciences (De Gruyter Open), Jg. 55 (2010-12-01), Heft 2, S. 212-215 |
Veröffentlichung: | 2010 |
Medientyp: | academicJournal |
ISSN: | 1896-1126 (print) |
DOI: | 10.2478/v10039-010-0019-2 |
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