The role of the Kinesin-13 family protein TbKif13-2 in flagellar length control of Trypanosoma brucei
In: Molecular & Biochemical Parasitology, Jg. 174 (2010-12-01), Heft 2, S. 137-140
Online
academicJournal
Zugriff:
Abstract: TbKif13-2, a member of the microtubule-depolymerising Kinesin-13 family was localised at the tip of the flagellum in Trypanosoma brucei. Its predicted activity suggested a role in the regulation of axonemal length. However, using gene deletion and overexpression of TbKif13-2 we show that, in procyclic T. brucei, this kinesin has only a very limited effect on flagellar length. Gene deletion resulted in no significant elongation of the flagellum and overexpression only slightly decreased flagellar length and the rate of growth of a new flagellum during cell division. This is in contrast to studies in Leishmania major, where overexpression of the TbKif13-2 homologue resulted in a significant length reduction of the flagellum. Knockout of TbKif13-2 has, however, an effect on the initial growth of the emerging new flagellum. In conclusion, we show that TbKif13-2 has only a marginal impact on flagellar length in T. brucei. [ABSTRACT FROM AUTHOR]
Titel: |
The role of the Kinesin-13 family protein TbKif13-2 in flagellar length control of Trypanosoma brucei
|
---|---|
Autor/in / Beteiligte Person: | Chan, Kuan Yoow ; Ersfeld, Klaus |
Link: | |
Zeitschrift: | Molecular & Biochemical Parasitology, Jg. 174 (2010-12-01), Heft 2, S. 137-140 |
Veröffentlichung: | 2010 |
Medientyp: | academicJournal |
ISSN: | 0166-6851 (print) |
DOI: | 10.1016/j.molbiopara.2010.08.001 |
Schlagwort: |
|
Sonstiges: |
|