Worldwide Diversity of Klebsiella pneumoniae That Produces β-Lactamase bla<subscript>KPC-2</subscript> Gene.
In: Emerging Infectious Diseases, Jg. 16 (2010-09-01), Heft 9, S. 1349-1356
Online
academicJournal
Zugriff:
Klebsiella pneumoniae isolates that produce carbapenemases (KPCs) are rapidly disseminating worldwide. To determine their genetic background, we investigate 16 blaKPC-2-harboring K. pneumoniae isolates from 5 countries. The isolates were multidrug resistant, possessed the blaKPC-2 gene, and differed by additional β-1actamase content. They harbored a naturally chromosome-encoded bla gene (blaSHV-1 [12.5%], blaSHV-11 [68.7%], or blaOKP-A/B [18.8%]) and several acquired and plasmid-encoded genes (blaTEM-1 [81.3%], blaCTX-M-2 [31.3%], blaCTX-M-12 [12.5%], blaCTX-M-15 [18.7%], and blaOXA-9 [37.5%]). The blaKPC-2 gene was always associated with 1 of the Tn4401 isoforms (a, b, or c). Tn4401 was inserted on different-sized plasmids that belonged to different incompatibility groups. Several blaKPC-Containing K. pneumoniae clones were found: 9 different pulsotypes with 1 major (sequence type 258) and 7 minor distinct at lelic profiles. Different clones harboring different plasmid but having identical genetic structure, Tn4401, could be a the origin of the worldwide spread of this emerging resistance gene. [ABSTRACT FROM AUTHOR]
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Worldwide Diversity of Klebsiella pneumoniae That Produces β-Lactamase bla<subscript>KPC-2</subscript> Gene.
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Autor/in / Beteiligte Person: | Naas, Gaële Cuzon Thierry ; Truong, Ha ; Vy ; Villegas, Maria-Virginia ; Wisell, Karin T. ; Carmeli, Yehuda ; Gales, Ana. C. ; Navon-Venezia, Shiri ; Quinn, John P. ; Nordmann, Patrice |
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Zeitschrift: | Emerging Infectious Diseases, Jg. 16 (2010-09-01), Heft 9, S. 1349-1356 |
Veröffentlichung: | 2010 |
Medientyp: | academicJournal |
ISSN: | 1080-6040 (print) |
DOI: | 10.3201/eid1609.091389 |
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