Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats
In: Brain Research, Jg. 1334 (2010-06-02), S. 58-64
Online
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Zugriff:
Abstract: N-methyl-d-aspartate (NMDA) receptor antagonists appear to enhance the anticonvulsant activity of antiepileptic drugs in several models of epilepsy. Therefore, the current study evaluates the modulatory effect of magnesium (Mg2+), a non-competitive NMDA receptor antagonist, on a subprotective dose of valproate (VPA) against pentylenetetrazol (PTZ)-induced convulsions. Male Wister rats received either saline or PTZ (60mg/kg, i.p.). The other three groups were pretreated with Mg2+ (40mg/kg, p.o., 4weeks), single subprotective dose of VPA (100mg/kg, i.p.), or Mg2+ with VPA, before PTZ injection. PTZ provoked clonic convulsions, reduced GABA content, deranged brain redox status, and elevated nitric oxide (NO). Neither the subprotective dose of VPA nor Mg2+ alone guarded against clonic seizures invoked by PTZ, an effect that was achieved only by their combination and supported by a significant delay in seizure latency. Moreover, VPA leveled off glycine and aspartate, exerted no effect on glutamate, and unexpectedly reduced GABA and taurine levels. Mg2+ alone or in combination showed the same pattern on the aforementioned amino acids, except for taurine. All regimens restored glutathione (GSH) and total antioxidant capacity (TAC); however, only VPA normalized NO level. This study demonstrates that Mg2+ could enhance the antiepileptic efficacy of a subprotective dose of VPA, possibly by improving redox balance and modulation of some brain amino acids. [Copyright &y& Elsevier]
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Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats
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Autor/in / Beteiligte Person: | Safar, Marwa M. ; Abdallah, Dalaal M. ; Arafa, Nadia M. ; Abdel-Aziz, Mohamed T. |
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Zeitschrift: | Brain Research, Jg. 1334 (2010-06-02), S. 58-64 |
Veröffentlichung: | 2010 |
Medientyp: | academicJournal |
ISSN: | 0006-8993 (print) |
DOI: | 10.1016/j.brainres.2010.03.076 |
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