8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer.
In: British Journal of Cancer, Jg. 102 (2010-03-15), Heft 6, S. 1018-1023
Online
academicJournal
Zugriff:
Background: 8-Hydroxydeoxyguanosine (8-oxodG) is the commonly used marker of oxidative stress-derived DNA damage. 8-OxodG formation is regulated by local antioxidant capacity and DNA repair enzyme activity. Earlier studies have reported contradictory data on the function of 8-oxodG as a prognostic factor in different cancer types. Methods: We assessed pre-operative serum 8-oxodG levels with an enzyme-linked immunosorbent assay in a well-defined series of 173 breast cancer patients. 8-OxodG expression in the nuclei of cancer cells from 150 of these patients was examined by immunohistochemistry. Results: The serum 8-oxodG levels and immunohistochemical 8-oxodG expression were in concordance with each other (P<0.05). Negative 8-oxodG immunostaining was an independent prognostic factor for poor breast cancer-specific survival according to the multivariate analysis (P<0.01). This observation was even more remarkable when ductal carcinomas only (n=140) were considered (P<0.001). A low serum 8-oxodG level was associated statistically significantly with lymphatic vessel invasion and a positive lymph node status. Conclusions: Low serum 8-oxodG levels and a low immunohistochemical 8-oxodG expression were associated with an aggressive breast cancer phenotype. In addition, negative 8-oxodG immunostaining was a powerful prognostic factor for breast cancer-specific death in breast carcinoma patients. [ABSTRACT FROM AUTHOR]
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8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer.
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Autor/in / Beteiligte Person: | Sova, H. ; Jukkola-Vuorinen, A. ; Puistola, U. ; Kauppila, S. ; Karihtala, P. |
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Zeitschrift: | British Journal of Cancer, Jg. 102 (2010-03-15), Heft 6, S. 1018-1023 |
Veröffentlichung: | 2010 |
Medientyp: | academicJournal |
ISSN: | 0007-0920 (print) |
DOI: | 10.1038/sj.bjc.6605565 |
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