Dengue Virus Infections and Maternal Antibody Decay in a Prospective Birth Cohort Study of Vietnamese Infants.
In: Journal of Infectious Diseases, Jg. 200 (2009-12-15), Heft 12, S. 1893-1900
Online
academicJournal
Zugriff:
Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of maternally derived DENV immunoglobulin (Ig) G and the incidence of DENV infection were determined in a prospectively studied cohort of 1244 Vietnamese infants. Higher concentrations of total IgG and DENV-reactive IgG were found in cord plasma relative to maternal plasma. Maternally derived DENV-neutralizing and E protein-reactive IgG titers declined to below measurable levels in 190% of infants by 6 months of age. In contrast, IgG reactive with whole DENV virions persisted until 12 months of age in 20% of infants. Serological surveillance identified 10 infants with asymptomatic DENV infection for an incidence of 1.7 cases per 100 person-years. DENV-neutralizing antibodies remained measurable for ⩾1 year after infection. These results suggest that whereas DENV infection in infants is frequently subclinical, there is a window between 4 and 12 months of age where virion-binding but nonneutralizing IgG could facilitate antibody-dependent enhancement. [ABSTRACT FROM AUTHOR]
Titel: |
Dengue Virus Infections and Maternal Antibody Decay in a Prospective Birth Cohort Study of Vietnamese Infants.
|
---|---|
Autor/in / Beteiligte Person: | Tran Nguyen Bich Chau ; Nguyen Trong Hieu ; Anders, Katherine L. ; Wolbers, Marcel ; Le Bich Lien ; Lu Thi Minh Hieu ; Tran Tinh Hien ; Nguyen Thanh Hung ; Farrar, Jeremy ; Whitehead, Stephen ; Simmons, Cameron P. |
Link: | |
Zeitschrift: | Journal of Infectious Diseases, Jg. 200 (2009-12-15), Heft 12, S. 1893-1900 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1086/648407 |
Schlagwort: |
|
Sonstiges: |
|