Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: An in vitro study
In: Brain Research, Jg. 1294 (2009-10-06), S. 144-152
Online
academicJournal
Zugriff:
Abstract: NXY-059, a polar compound with limited transport across the blood-brain barrier, has demonstrated neuroprotection in several animal models of acute ischemic stroke but failed to confirm clinical benefit in the second phase III trial (SAINT-II). To improve the understanding of the mechanisms responsible for its neuroprotective action in preclinical models a series of experiments was carried out in an in vitro blood-brain barrier (BBB) model. A clinically attainable concentration of 250 μmol/L of NXY-059 administered at the onset or up to 4 h after oxygen glucose deprivation (OGD) produced a significant reduction in the increased BBB permeability caused by OGD. Furthermore, OGD produced a huge influx of tissue plasminogen activator across the BBB, which was substantially reduced by NXY-059. This study suggests that the neuroprotective effects of NXY-059 preclinically, may at least in part be attributed to its ability to restore functionality of the brain endothelium. [Copyright &y& Elsevier]
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Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: An in vitro study
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Autor/in / Beteiligte Person: | Culot, Maxime ; Mysiorek, Caroline ; Renftel, Mila ; Roussel, Benoit D. ; Hommet, Yannick ; Vivien, Denis ; Cecchelli, Roméo ; Fenart, Laurence ; Berezowski, Vincent ; Dehouck, Marie-Pierre ; Lundquist, Stefan |
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Zeitschrift: | Brain Research, Jg. 1294 (2009-10-06), S. 144-152 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0006-8993 (print) |
DOI: | 10.1016/j.brainres.2009.07.035 |
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