A mechanism for axonal transport defects in HD.
In: Nature Reviews Neurology, Jg. 5 (2009-09-01), Heft 9, S. 464-464
Online
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Zugriff:
The article discusses research on the mechanism for axonal transport defects in Huntington disease (HD). It references the study "Pathogenic Huntingtin Inhibits Fast Axonal Transport by Activating JNK3 and Phosphorylating Kinesin," by Gerardo A. Morfini et al published in a 2009 issue of "Nature Neuroscience." They found that cJun N-terminal kinase (JNK) 3 inhibitors blocked the inhibitory effect of mutant huntingtin protein (HTT) on axonal transport in squid axoplasm. They also concluded that mutant HTT expression increases JNK activity in HD.
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A mechanism for axonal transport defects in HD.
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Autor/in / Beteiligte Person: | Yates, Darran |
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Zeitschrift: | Nature Reviews Neurology, Jg. 5 (2009-09-01), Heft 9, S. 464-464 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 1759-4758 (print) |
DOI: | 10.1038/nrneurol.2009.120 |
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