ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.
In: Proceedings of the National Academy of Sciences of the United States of America, Jg. 106 (2009-05-12), Heft 19, S. 7945-7950
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Zugriff:
IFN-stimulated gene 56 (1SG56) is one of the first identified proteins induced by viruses and type I IFNs. In this study, we identified 1SG56 as a virus-induced protein associated with MITA, an adapter protein involved in virus-triggered induction of type I IFNs. Over-expression of 1SG56 inhibited Sendai virus-triggered activation of IRF3, NF-κB, and the IFN-β promoter, whereas knockdown of 1SG56 had opposite effects. Consistently, overexpression of 1SG56 re- versed. cytoplasmic poly(I:C)-induced inhibition of vesicular stomatitis virus (VSV) replication, whereas knockdown of ISG56 inhibited VSV replication. Competitive coimmunoprecipitation experiments indicated that 1SG56 disrupted the interactions between MITA and VISA or TBK1, two components in the virus-triggered IFN signaling pathways. These results suggest that 1SG56 is a mediator of negative-feedback regulation of virus-triggered induction of type I IFNs and cellular antiviral responses. [ABSTRACT FROM AUTHOR]
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ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.
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Autor/in / Beteiligte Person: | Li, Ying ; Li, Chao ; Xue, Peng ; Zhong, Bo ; Mao, Ai-Ping ; Ran, Yong ; Chen, He ; Wang, Yan-Yi ; Yang, Fuquan ; Shu, Hong-Bing |
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Zeitschrift: | Proceedings of the National Academy of Sciences of the United States of America, Jg. 106 (2009-05-12), Heft 19, S. 7945-7950 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0027-8424 (print) |
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