Ca<superscript>2+</superscript>-Calmodulin Feedback Mediates Sensory Adaptation and Inhibits Pheromone-Sensitive Ion Channels in the Vomeronasal Organ.
In: Journal of Neuroscience, Jg. 29 (2009-02-18), Heft 7, S. 2125-2135
Online
academicJournal
Zugriff:
The mammalian vomeronasal organ (VNO) mediates the regulation of social behaviors by complex chemical signals. These cues trigger transient elevations of intracellular Ca2+ in vomeronasal sensory neurons (VSNs), but the functional role of such Ca2+ elevations is unknown. We show that stimulus-induced Ca2+ entry plays an essential role as a negative feedback regulator of VSN sensitivity. Electrophysiological VSN responses undergo effective sensory adaptation that requires the influx of Ca2+ and is mediated by calmodulin (CaM). Removal of the Ca2+-CaM feedback eliminates this form of adaptation. A key target of this feedback module is the pheromonesensitive TRPC2+-dependent cation channel of VSNs, as its activation is strongly inhibited by Ca2+-CaM. Our results reveal a previously unrecognized CaM-signaling pathway that endows the VSNs with a mechanism for adjusting gain and sensitivity of chemosensory signaling in the VNO. [ABSTRACT FROM AUTHOR]
Titel: |
Ca<superscript>2+</superscript>-Calmodulin Feedback Mediates Sensory Adaptation and Inhibits Pheromone-Sensitive Ion Channels in the Vomeronasal Organ.
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Autor/in / Beteiligte Person: | Spehr, Jennifer ; Hagendorf, Silke ; Weiss, Jan ; Spehr, Marc ; Leinders-Zufall, Trese ; Zufall, Frank |
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Zeitschrift: | Journal of Neuroscience, Jg. 29 (2009-02-18), Heft 7, S. 2125-2135 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0270-6474 (print) |
DOI: | 10.1523/JNEUROSCI.5416-08.2009 |
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