Xenopus cadherin-6 regulates growth and epithelial development of the retina
In: Mechanisms of Development, Jg. 123 (2006-12-01), Heft 12, S. 881-892
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Zugriff:
Abstract: Cadherins are crucial for tissue cohesion, separation of cell layers and cell migration during embryogenesis. To investigate the role of classical type II Xcadherin-6 (Xcad-6), we performed loss-of-function studies by morpholino oligonucleotide injections. This resulted in severe eye defects which could be rescued with murine cadherin-6. In the absence of Xcadherin-6, morphological alterations and a decrease in cell proliferation were observed with eye cup formation. Eye field transplantations of Xcadherin-6 depleted donors yielded grafts that failed to form a proper neuroepithelium in a wildtype environment. At later developmental stages Xcadherin-6 deficient eyes showed lamination defects in the outer neural retina, a reduced thickness of the ganglion cell layer (GCL) and a fragmented retina pigment epithelium (RPE). Thus, Xcadherin-6 is essential early in eye development for structural organization and growth of the neuroepithelium before it differentiates into neural retina and RPE. [Copyright &y& Elsevier]
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Xenopus cadherin-6 regulates growth and epithelial development of the retina
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Autor/in / Beteiligte Person: | Ruan, Gui ; Wedlich, Doris ; Koehler, Almut |
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Zeitschrift: | Mechanisms of Development, Jg. 123 (2006-12-01), Heft 12, S. 881-892 |
Veröffentlichung: | 2006 |
Medientyp: | academicJournal |
ISSN: | 0925-4773 (print) |
DOI: | 10.1016/j.mod.2006.08.010 |
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