Cytoplasmic Listeria monocytogenes stimulates IFN-β synthesis without requiring the adapter protein MAVS
In: FEBS Letters, Jg. 580 (2006-04-17), Heft 9, S. 2341-2346
Online
academicJournal
Zugriff:
Abstract: The mitochondria-associated adapter protein MAVS (also called IPS-1, VISA or CARDIF, designated MAVS for reasons of simplicity in our manuscript) relays signals from cytoplasmic sensors of viral RNA to the IRF3 kinase complex and the interferon-β (IFN-β) gene. Using siRNA-mediated knock-down in macrophages we show that IFN-β synthesis in response to transfected, intracellular double-stranded RNA (dsRNA), a pathogen-associated molecular pattern of viruses, is decreased in absence of MAVS. By contrast, the Gram-positive bacterium Listeria monocytogenes targets the IFN-β gene without detectable MAVS requirement. The data show that MAVS is not a central adapter protein for all cytoplasmic pathogen sensors that stimulate IFN-β synthesis. [Copyright &y& Elsevier]
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Cytoplasmic Listeria monocytogenes stimulates IFN-β synthesis without requiring the adapter protein MAVS
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Autor/in / Beteiligte Person: | Soulat, Didier ; Bauch, Angela ; Stockinger, Silvia ; Superti-Furga, Giulio ; Decker, Thomas |
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Zeitschrift: | FEBS Letters, Jg. 580 (2006-04-17), Heft 9, S. 2341-2346 |
Veröffentlichung: | 2006 |
Medientyp: | academicJournal |
ISSN: | 0014-5793 (print) |
DOI: | 10.1016/j.febslet.2006.03.057 |
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