Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB<subscript>1</subscript> and CB<subscript>2</subscript> receptor coupled pathways
In: International Immunopharmacology, Jg. 6 (2006-04-01), Heft 4, S. 656-665
Online
academicJournal
Zugriff:
Abstract: There is a great interest in the pharmacological properties of cannabinoid like compounds that are not linked to the adverse effects of Δ9-tetrahydrocannabinol (THC), e.g. psychoactive properties. The present paper describes the potential immuno-modulating activity of unheated Cannabis sativa extracts and its main non-psychoactive constituent Δ9-tetrahydrocanabinoid acid (THCa). By heating Cannabis extracts, THCa was shown to be converted into THC. Unheated Cannabis extract and THCa were able to inhibit the tumor necrosis factor alpha (TNF-α) levels in culture supernatants from U937 macrophages and peripheral blood macrophages after stimulation with LPS in a dose-dependent manner. This inhibition persisted over a longer period of time, whereas after prolonged exposure time THC and heated Cannabis extract tend to induce the TNF-α level. Furthermore we demonstrated that THCa and THC show distinct effects on phosphatidylcholine specific phospholipase C (PC-PLC) activity. Unheated Cannabis extract and THCa inhibit the PC-PLC activity in a dose-dependent manner, while THC induced PC-PLC activity at high concentrations. These results suggest that THCa and THC exert their immuno-modulating effects via different metabolic pathways. [Copyright &y& Elsevier]
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Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB<subscript>1</subscript> and CB<subscript>2</subscript> receptor coupled pathways
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Autor/in / Beteiligte Person: | Verhoeckx, Kitty C.M. ; Korthout, Henrie A.A.J. ; van Meeteren-Kreikamp, A.P. ; Ehlert, Karl A. ; Wang, Mei ; van der Greef, Jan ; Rodenburg, Richard J.T. ; Witkamp, Renger F. |
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Zeitschrift: | International Immunopharmacology, Jg. 6 (2006-04-01), Heft 4, S. 656-665 |
Veröffentlichung: | 2006 |
Medientyp: | academicJournal |
ISSN: | 1567-5769 (print) |
DOI: | 10.1016/j.intimp.2005.10.002 |
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