Nitrones as therapeutics in age-related diseases.
In: Aging Cell, Jg. 5 (2006-02-01), Heft 1, S. 51-57
Online
academicJournal
Zugriff:
Age-related diseases deprive individuals of a higher quality of life and therefore therapeutics for their treatment provide significant potential. An overview of the observations of nitrones as potential therapeutics in several age-related diseases is presented. Treatment of acute ischemic stroke is one condition where a nitrone (NXY-059) is in late phase 3 clinical trials now. Also presented is a summary of the most recent work we have accomplished on the anticancer activity of the nitrones in a hepatocellular carcinoma. The mechanistic basis of action of these compounds in several animal models is not yet understood at the molecular levels; however, it does appear clear that their anti-inflammatory properties are central to their action, which is based on their ability to down-regulate exacerbated signal transduction processes. [ABSTRACT FROM AUTHOR]
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Nitrones as therapeutics in age-related diseases.
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Autor/in / Beteiligte Person: | Floyd, Robert A. |
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Zeitschrift: | Aging Cell, Jg. 5 (2006-02-01), Heft 1, S. 51-57 |
Veröffentlichung: | 2006 |
Medientyp: | academicJournal |
ISSN: | 1474-9718 (print) |
DOI: | 10.1111/j.1474-9726.2006.00189.x |
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