The dual coding of a single sex pheromone receptor in Asian honeybee Apis cerana.
In: Communications Biology, Jg. 7 (2024-04-25), Heft 1, S. 1-9
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Zugriff:
In Asian honeybees, virgin queens typically only mate during a single nuptial flight before founding a colony. This behavior is controlled by the queen-released mandibular pheromone (QMP). 9-oxo-(E)-2-decenoic acid (9-ODA), a key QMP component, acts as sex pheromone and attracts drones. However, how the queens prevent additional mating remains elusive. Here, we show that the secondary QMP component methyl p-hydroxybenzoate (HOB) released by mated queens inhibits male attraction to 9-ODA. Results from electrophysiology and in situ hybridization assay indicated that HOB alone significantly reduces the spontaneous spike activity of 9-ODA-sensitive neurons, and AcerOr11 is specifically expressed in sensilla placodea from the drone's antennae, which are the sensilla that narrowly respond to both 9-ODA and HOB. Deorphanization of AcerOr11 in Xenopus oocyte system showed 9-ODA induces robust inward (regular) currents, while HOB induces inverse currents in a dose-dependent manner. This suggests that HOB potentially acts as an inverse agonist against AcerOr11. Identifying HOB, a substance of the queen mandibular pheromone, as an anti-aphrodisiac in Asian honeybee chemical communication. [ABSTRACT FROM AUTHOR]
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The dual coding of a single sex pheromone receptor in Asian honeybee Apis cerana.
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Autor/in / Beteiligte Person: | Ke, Haoqin ; D. Bohbot, Jonathan ; Chi, Yongjuan ; Duan, Shiwen ; Ma, Xiaomei ; Ren, Bingzhong ; Wang, Yinliang |
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Zeitschrift: | Communications Biology, Jg. 7 (2024-04-25), Heft 1, S. 1-9 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 2399-3642 (print) |
DOI: | 10.1038/s42003-024-06206-5 |
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