REFERENCE INTERVALS OF BIOCHEMICAL PARAMETERS IN CHILEAN ADULTS.
In: Journal of Medical Biochemistry, Jg. 43 (2024), Heft 1, S. 133-143
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Zugriff:
Background: Establishing reference intervals (RIs) in clinical laboratories is essential, as these can vary due to inter-individual variability as well as the analytical methods used. The purpose of this study was to determine RIs for markers and ratios biochemical in apparently healthy Chilean adults. Methods: A sample of 1,143 data was selected from the Universidad Catdlica de Temuco, Clinical Laboratory database, La Araucanfa Region, Chile, which were analysed by sex. The Tukey's Fences was used to detect outliers and the RIs were established using the non-parametric method. Results: The RIs obtained for the female sex were: Urea 2.48-7.35 mmol/L AST 0.20-0.69 pkat/L ALT 0.13-1.12 jikat/L, Alkaline Phosphatase 0.83-2.5 pkat/L Total Bilirubin 3.5-17.3 mmol/L, Direct Bilirubin 1.5-4.9 mmol/L, Uric Acid 148-362 mmol/L and Total Proteins 66.3-80.3 g/L and for males: Urea 3.28-8.17 mmol/L AST 0.22-0.80 pkat/L ALT 0.18-1.9 pkat/L Alkaline Phosphatase 0.93-2.33 pkat/L Total Bilirubin 4.58-24.0 mmol/L, Direct Bilirubin 1.9-7.5 mmol/L Uric Acid 202-458 mmol/L and Total Proteins 67.4-83 g/L. The FIB-4 and APRI index presented a range of 0.2-1.6 and 0.12-0.5 respectively (in both genders) and the AST/ALT index was 0.5-2 in women and 0.38-1.66 in men. Conclusion: A panel of Rls for locally-relevant biochemical parameters has been established, this study being the first to be carried out in our country. When comparing these results with other studies and those reported by reagent manufacturers, some differences were observed. This study thus contributes to increase the reliability in the interpretation of laboratory results and therefore to the clinical management of patients. [ABSTRACT FROM AUTHOR]
Uvod: Uspostavljanje referentnih intervala (Rl) u kliničkim laboratorijama je od suštinskog značaja, jer oni mogu varirati zbog varijabilnosti među pojedincima, kao i zbog korišćenih analitičkih metoda. Svrha ove studije je bila da se odredi Rl za markere i biohemijske odnose kod naizgled zdravih odraslih Čilea nača. Metode: Uzorak od 1.143 podataka odabran je iz baze podataka Universidad Catćlica de Temuco, kliničke laboratorije, La Araucanfa Region, Čile, koji su analizirani prema polu. Tukei's Fences je korišćen za otkrivanje odstupanja, a Rl su uspostavljeni korišćenjem neparametarske metode. Rezultati: Dobijeni Rl za ženski pol su: urea 2,48-7,35 mmol/L, AST 0,20-0,69, ukat/L, ALT 0,13-1,12 ukat/L, alkalna fosfataza 0,83-2,5 ukat/L, ukupni bilirubin 3,3 I-7 jukat/L L, direktni bilirubin 1,5-4,9 umol/L, mokraćna kiselina 148-362 umol/L i ukupni proteini 66,3-80,3 g/L i za muškarce: urea 3,28-8,17 mmol/L, AST 0,22-0,8, ALT 0,18-1,9, ukat/L, alkalna fosfataza 0,93-2,33 ukat/L, ukupan bilirubin 4,58-24,0 umol/L, direktni bilirubin 1,9-7,5 umol/L, mokraćna kiselina 202-458 mmol/L i ukupni proteini 67,4-83 g/L. FIB-4 i APRI indeksi su predstavljali raspon od 0,2-1,6 i 0,12-0,5 (uoba pola), a AST/ALT indeks je bio 0,5-2 kod žena i 0,38-1,66 kod muškaraca. Zaključak: Formiran je panel Rl za lokalno relevantne bio-hemijske parametre, ova studija je prva koja je sprovedena u našoj zemlji. Prilikom upoređivanja ovih rezultata sa drugim studijama i onima koje su prijavili proizvođači reagensa, uočene su neke razlike. Ova studija na taj način doprinosi povećanju pouzdanosti u tumačenju laboratorijskih rezultata, a samim tim i kliničkom vođenju pacijenata. [ABSTRACT FROM AUTHOR]
Titel: |
REFERENCE INTERVALS OF BIOCHEMICAL PARAMETERS IN CHILEAN ADULTS.
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Autor/in / Beteiligte Person: | Letelier, Pablo ; Acuña, Rodban ; Garrido, Ignacio ; López, Jorge ; Sanhueza, Guillermo ; Seguel, Caren ; Riquelme, Ismael ; Guzmán, Neftalí ; Hernández, Alfonso H. |
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Zeitschrift: | Journal of Medical Biochemistry, Jg. 43 (2024), Heft 1, S. 133-143 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1452-8258 (print) |
DOI: | 10.5937/jomb0-44156 |
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