Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway.
In: Journal of Ethnopharmacology, Jg. 322 (2024-03-25), S. N.PAG
Online
academicJournal
Zugriff:
Naoxinqing (NXQ) tablets are derived from persimmon leaves and are widely used in China for promoting blood circulation and removing blood stasis in China. We aimed to explore whether NXQ has the therapeutic effect on ischemic stroke and explored its possible mechanism. The cerebral artery occlusion/reperfusion (MCAO/R) surgery was used to establish the cerebral ischemic/reperfusion rat model. NXQ (60 mg/kg and 120 mg/kg) were administered orally. The TTC staining, whole brain water content, histopathology staining, immunofluorescent staining, enzyme-linked immunosorbent assay (ELISA) and Western blot analyses were performed to determine the therapeutical effect of NXQ on MCAO/R rats. The study demonstrated that NXQ reduced the cerebral infarction volumes and neurologic deficits in MCAO/R rats. The neuroprotective effects of NXQ were accompanied by inhibited oxidative stress and inflammation. The nerve regeneration effects of NXQ were related to regulating the AMPKα/NAMPT/SIRT1/PGC-1α pathway. In summary, our results revealed that NXQ had a significant protective effect on cerebral ischemia-reperfusion injury in rats. This study broadens the therapeutic scope of NXQ tablets and provides new neuroprotective mechanisms of NXQ as an anti-stroke therapeutic agent. [Display omitted] • Naoxinqing showed significant neuroprotective effects on cerebral ischemia-reperfusion injury in rats. • Naoxinqing inhibited cellular apoptosis, inflammatory response and oxidative stress and promoted nerve regeneration. • AMPKα/NAMPT/SIRT1/PGC-1α pathway was involved in the protective effects of Naoxinqing. [ABSTRACT FROM AUTHOR]
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Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway.
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Autor/in / Beteiligte Person: | Sun, Xiao ; Pan, Yunfeng ; Luo, Yun ; Guo, Haibiao ; Zhang, Zhixiu ; Wang, Deqin ; Li, Chuyuan ; Sun, Xiaobo |
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Zeitschrift: | Journal of Ethnopharmacology, Jg. 322 (2024-03-25), S. N.PAG |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0378-8741 (print) |
DOI: | 10.1016/j.jep.2023.117672 |
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