Monitoring of ionized magnesium in hemodialysis patients: A useful tool to allow a personalized prescription of dialysate composition.
In: Clinica Chimica Acta, Jg. 552 (2024), S. N.PAG
Online
academicJournal
Zugriff:
• Citrate 0.75 mM Mg led to a neutral balance (0.02 mmol/l) based on iMg. • Mg changes during the session depends on pre-dialysis levels and dialysate composition. • Increasing the concentration to 0.75 mM significantly raises post-dialysis Mg. • 95.4% of the patients achieved a positive balance using Acetate 0.75 mM Mg. • 56% of the patients achieved a positive balance using Citrate 0.75 mM Mg. • Monitoring iMg should allow a personalized prescription of dialysate Mg. The dialysate magnesium (Mg) concentration is a major determinant of Mg balance in hemodialysis. This study aimed to assess the systemic variations of total (tMg) and ionized Mg (iMg) during a dialysis session using acetate or citrate fluids and 0.5 or 0.75 mM Mg. 134 patients in maintenance hemodialysis were assigned to a dialysis session with 4 different dialysates: acetate fluid with 0.5 mM Mg (1) or 0.75 mM Mg (2), citrate fluid with 0.5 mM Mg (3) or 0.75 mM Mg (4). Ionized form was measured by direct ion-selective electrode. A Mg loss was observed in both acetate (0.12 and 0.08 mmol/L) and citrate (0.13 and 0.14 mmol/L for tMg and iMg, respectively) fluid groups containing 0.5 mM Mg. The use of acetate and citrate dialysates with 0.75 mM Mg led to a significant median intra-dialytic increase of 0.15 and 0.08 mmol/L for tMg, respectively. A significant augmentation in iMg concentration with acetate (0.11 mmol/L) but not with citrate dialysate (0.02 mmol/L) was observed. While a dialysate Mg concentration at 0.5 mM leads to a negative balance, increasing the concentration to 0.75 mM significantly raises post-dialysis circulating Mg. Monitoring of iMg should allow a personalized prescription in dialysate Mg. [ABSTRACT FROM AUTHOR]
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Monitoring of ionized magnesium in hemodialysis patients: A useful tool to allow a personalized prescription of dialysate composition.
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Autor/in / Beteiligte Person: | Bargnoux, Anne-Sophie ; Morena, Marion ; Rodriguez, Annie ; Courtais-Coulon, Caroline ; Dupuy, Anne-Marie ; Kuster, Nils ; Chalabi, Lotfi ; Cristol, Jean-Paul |
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Zeitschrift: | Clinica Chimica Acta, Jg. 552 (2024), S. N.PAG |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0009-8981 (print) |
DOI: | 10.1016/j.cca.2023.117687 |
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