Adverse Drug Reactions to Antiretroviral Therapy: Frequency, Type, and Risk Factors in Children in Mali.
In: Journal of Pediatric Pharmacology & Therapeutics, Jg. 28 (2023-04-01), Heft 3, S. 197-203
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Zugriff:
OBJECTIVE The aim of our study was to evaluate the frequency, type, and risk factors associated with adverse drug reactions (ADRs) in HIV-positive children with adherence to antiretroviral therapy (ART) at the Unit of Care and Accompaniment for People Living With HIV (USAC) of Bamako. METHODS A cross-sectional study was conducted at USAC of Bamako from May 1, 2014, to July 31, 2015. We included children aged 1 to 14 years with at least 6 months of ARV treatment initiated at USAC, with or without ADRs. Data collection was based on information collected from parents and clinical/biological assessments. RESULTS Median age of participants was 36 months and female sex was predominant (54.8%). Poor adherence during the study was observed in 15% of cases. Of patients in the study, 52% had a CD4 count less than 350 cells/mm³ at the time of adverse events. In bivariate analysis, we found that participants with adherence to ART tended to be younger than those with non-adherence to ART (36 vs 72 months, p = 0.093). In multivariable analysis, prophylactic treatment was the only factor marginally associated with ART adherence in HIV patients (p = 0.09). No other adverse biological effects or clinical conditions were associated with ART adherence in this study. CONCLUSIONS In this study we found that ADRs were frequent in HIV-positive patients but less frequent in ART-adherent HIV-positive children. Therefore, it is essential to regularly monitor children receiving ARVs to detect and treat the complications associated with these therapies according to ART adherence. [ABSTRACT FROM AUTHOR]
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Adverse Drug Reactions to Antiretroviral Therapy: Frequency, Type, and Risk Factors in Children in Mali.
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Autor/in / Beteiligte Person: | Oumar, Aboubacar Alassane ; Seydou, Alassane ; Fofana, Souleymane ; Diarra, Zoumana ; Mariko, Djeneba ; Diallo, Abdallah ; Coulibaly, Sanata ; Sidibe, Lala N. ; Togo, Boubacar ; Dao, Sounkalo ; Doumbia, Seydou ; Tulkens, Paul M. |
Zeitschrift: | Journal of Pediatric Pharmacology & Therapeutics, Jg. 28 (2023-04-01), Heft 3, S. 197-203 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1551-6776 (print) |
DOI: | 10.5863/1551-6776-28.3.197 |
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