IDENTIFICATION OF SERUM miR-378 AND miR-575 AS DIAGNOSTIC INDICATORS AND PREDICTING SURGICAL PROGNOSIS IN HUMAN EPILEPSY.
In: Journal of Medical Biochemistry, Jg. 41 (2022-04-01), Heft 2, S. 184-190
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Zugriff:
Background: Epilepsy (EP) is a common neurological disorder which is characterized by excessive abnormal synchronization of neuronal discharges in the brain due to chronic recurrent seizures of multiple etiologies. Variety of microRNAs have been associated with the occurrence and development of EP. This study aimed to determine the aberrant expression of miR-378 and miR-575 in EP patients to validate their potential to distinguish EP from healthy patients. Methods: RT-qPCR was used to determine the expressions of miR-378 and miR-575 from serum specimens of 106 EP and 103 control individuals. Clinical indicators between EP patients and controls were assessed. Based on surgical outcome, EP patients were further divided into Engel I--IV EP. The potentials of miR-378 and miR-575 in discriminating EP from healthy participants and predicting surgical prognosis were calculated by receiver operating characteristic (ROC) analysis. Results: We found the miR-378 and miR-575 were significantly declined (P<0.001) in Engel I-II and III--IV EP patients with no difference in clinical parameters compared. Moreover, miR-378 and miR-575 displayed high sensitivity, specificity, and accuracy in distinguishing EP patients and predicting surgical outcomes. Moreover, after surgical treatment, miR-378 and miR-575 levels were increased compared with those at admission, suggesting their potentials in treatment response. Conclusions: miR-378 and miR-575 could be utilized as novel and non-invasive serum biomarkers in discriminating EP from healthy controls and predicting surgical outcome, shedding new insights on epileptogenesis and EP treatment. [ABSTRACT FROM AUTHOR]
Uvod: Epilepsija (EP) je uobičajen neurološki poremećaj koji se karakteriše prekomernom sinhronizacijom pražnjenja neurona u mozgu usled hroničnih ponovljenih napada različitih etiologija. Različite mikro RNK su povezane sa pojavom i razvojem EP. Ova studija je imala za cilj da odredi aberantnu ekspresiju miR-378 i miR-575 kod pacijenata sa EP kako bi potvrdila njihov potencijal da se ustanovi razlika između pacijenata sa EP i zdravih pacijenata. Metode: RT-qPCR je korišćen da bi se odredila ekspresija miR-378 i miR-575 iz serumskih uzoraka 106 pacijenata sa EP i 103 kontrolna ispitanika. Izvršena je procena kliničkih pokazatelja kod pacijenata sa EP i kontrolnih ispitanika. Na osnovu ishoda hirurškog lečenja, pacijenti sa EP su dalje podeljeni na Engel I--IV ER Analizom krive operativnih karakteristika (ROC) izračunat je potencijal koji imaju miR-378 i miR-575 i koji karakteriše pacijente sa EP u odnosu na zdrave učesnike istraživanja kako bi se pred- video tok lečenja. Rezultati: Utvrdili smo da su miR-378 i miR-575 značajno smanjeni (P < 0,001) kod pacijenata sa Engel I--II i III--IV EP bez razlika u upoređenim kliničkim parametrima. Šta- više, miR-378 i miR-575 su pokazali visoku osetljivost, specifičnost i tačnost u razlikovanju EP pacijenata i predviđanju ishoda. Dalje, nakon hirurškog lečenja, nivoi miR-378 i miR-575 su povećani u poređenju sa onima pri prijemu, što ukazuje na njihov potencijal u rekaciji na lečenje. Zaklju~ak: miR-378 i miR-575 se mogu koristiti kao novi i neinvazivni biomarkeri u serumu za diferencijaciju pacijenata sa EP od zdravih kontrolnih ispitanika i predviđanje hirurškog ishoda, otkrivajući nove uvide u epileptogenezu i lečenje EP. [ABSTRACT FROM AUTHOR]
Titel: |
IDENTIFICATION OF SERUM miR-378 AND miR-575 AS DIAGNOSTIC INDICATORS AND PREDICTING SURGICAL PROGNOSIS IN HUMAN EPILEPSY.
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Autor/in / Beteiligte Person: | Li, XiuXiu ; Gao, ZhiQing ; Mei Ling Ma ; Li, Li ; Guo, ShiFeng |
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Zeitschrift: | Journal of Medical Biochemistry, Jg. 41 (2022-04-01), Heft 2, S. 184-190 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1452-8258 (print) |
DOI: | 10.5937/jomb0-32988 |
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