Measurement of neurofilaments improves stratification of future disease activity in early multiple sclerosis.
In: Multiple Sclerosis Journal, Jg. 27 (2021-11-01), Heft 13, S. 2001-2013
Online
academicJournal
Zugriff:
Background: The added value of neurofilament light chain levels in serum (sNfL) to the concept of no evidence of disease activity-3 (NEDA-3) has not yet been investigated in detail. Objective: To assess whether combination of sNfL with NEDA-3 status improves identification of patients at higher risk of disease activity during the following year. Methods: We analyzed 369 blood samples from 155 early relapsing-remitting MS patients on interferon beta-1a. We compared disease activity, including the rate of brain volume loss in subgroups defined by NEDA-3 status and high or low sNfL (> 90th or < 90th percentile). Results: In patients with disease activity (EDA-3), those with higher sNFL had higher odds of EDA-3 in the following year than those with low sNFL (86.5% vs 57.9%; OR = 4.25, 95% CI: [2.02, 8.95]; p = 0.0001) and greater whole brain volume loss during the following year (β = −0.36%; 95% CI = [−0.60, −0.13]; p = 0.002). Accordingly, NEDA-3 patients with high sNfL showed numerically higher disease activity (EDA-3) in the following year compared with those with low sNfL (57.1% vs 31.1%). Conclusion: sNfL improves the ability to identify patients at higher risk of future disease activity, beyond their NEDA-3 status. Measurement of sNfL may assist clinicians in decision-making by providing more sensitive prognostic information. [ABSTRACT FROM AUTHOR]
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Measurement of neurofilaments improves stratification of future disease activity in early multiple sclerosis.
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Autor/in / Beteiligte Person: | Uher, Tomas ; Havrdova, Eva Kubala ; Benkert, Pascal ; Bergsland, Niels ; Krasensky, Jan ; Srpova, Barbora ; Dwyer, Michael ; Tyblova, Michaela ; Meier, Stephanie ; Vaneckova, Manuela ; Horakova, Dana ; Zivadinov, Robert ; Leppert, David ; Kalincik, Tomas ; Kuhle, Jens |
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Zeitschrift: | Multiple Sclerosis Journal, Jg. 27 (2021-11-01), Heft 13, S. 2001-2013 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 1352-4585 (print) |
DOI: | 10.1177/13524585211047977 |
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