仅通过饮食和运动控制血糖的绝经后 2 型糖尿病 患者中血脂、骨代谢与骨密度的相关性研究.

Objective To investigate the relationship between serum lipid, bone metabolism and bone metabolism density ( BMD) in postmenopausal patients with type 2 diabetes mellitus ( TIDM) treated with diet and exercise only. Methods A total of 105 patients with TIDM treated in the Department of Endocrinology, People's Hospital of Ningxia Hui Autonomous Region from January 2018 to January 2020 were enrolled. Their ages were from 45 to 70 years old. The course of diabetes, height, weight, body mass index (BMI), serum lipid (TC, TG, HDL, LDL), and glycosylated hemoglobin (HbAlc) were recorded. BMD of the lumbar spine ( L1-4), femoral Neck (neck), trochanter ( Troch), and Ward triangle ( Wards) of the subjects were measured with dual energy X-ray absorptiometry and were statistically analyzed. Results With the increase of age, BMD showed a downward trend. Age, course of disease, glycosylated hemoglobin, TG, LDL, PTH, OC, TPINP, and r: β-CTX were negatively correlated with BMD in various parts. BMI and 25-0H-D were positively correlated with BMD of each part. Multiple stepwise regression analysis showed that glycosylated hemoglobin, TG, LDL, and TPINP were negatively correlated with BMD, while 25-0H-D was positively correlated with BMD. Conclusion Postmenopausal patients with type 2 diabetes should pay attention to vitamin D supplementation, good control of blood glucose, comprehensive examination of blood lipid and bone metabolism, and early control of risk factors related to osteoporosis. [ABSTRACT FROM AUTHOR]

目的分析在仅通过饮食和运动控制血糖的绝经后2型糖尿病患者中血脂､骨代谢与骨密度的相关性。方法纳入 2018年1月至2020年1月在宁夏回族自治区人民医院内分泌科治疗的 105 例2 型糖尿病患者,年龄45-70岁。记录受试者 的糖尿病病程身高体重、体质量指数(body mass index, BMI), 检测血脂 (TC.TG､HDLLDL) 糖化血红蛋白 (HbAle)。采用 双能X线骨密度仪测定受试者腰椎(L)股骨颈( Neck)、大转子(Troch) 和 Ward 三角(Wards)的骨密度 (bone mineral density, BMD), 并进行统计学分析 结果 随年龄增高骨密度呈下降趋势,年龄、病程､糖化血红蛋白、TG、LDL.PTH OC、 TPINPB-CTX 与各部位的骨密度呈负相关:BMI 25(OH)D 与各部位的骨密度呈正相关;多元逐步回归分析显示糖化血红蛋 白.TG LDL TPINP 与骨密度存在负相关,25(OH)D 与骨密度正相关。结论绝经后2型糖尿病患者应注意补充维生素D制 剂,良好控制血糖,全面檢查血脂,骨代谢,尽早对骨质疏松相关危险因素进行管控. [ABSTRACT FROM AUTHOR]