TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking.
In: Acta Neuropathologica, Jg. 142 (2021-07-01), Heft 1, S. 217-221
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Keywords: ALS; FTD; iPSC; TBK 1; Membrane trafficking; Neurons EN ALS FTD iPSC TBK 1 Membrane trafficking Neurons 217 221 5 06/23/21 20210701 NES 210701 Supplementary Information The online version contains supplementary material available at https://doi.org/10.1007/s00401-021-02331-1. Values are mean ± SEM t test To study TBK1 haploinsufficiency and model ALS/FTD in human neurons, we differentiated one parental and two I TBK1 i SP -/+ sp iPSC lines into postmitotic neurons. These proteins included some known TBK1-interacting proteins such as TANK, TBKBP1, optineurin, AZI2, TRAF2, and syntaxin 17, as well as many potentially novel TBK1-interacting proteins such as several t-SNARE proteins, including syntaxins 4, 7, 12, 17, and 18 (Fig. [Extracted from the article]
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TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking.
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Autor/in / Beteiligte Person: | Lu, Yubing ; Almeida, Sandra ; Gao, Fen-Biao |
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Zeitschrift: | Acta Neuropathologica, Jg. 142 (2021-07-01), Heft 1, S. 217-221 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0001-6322 (print) |
DOI: | 10.1007/s00401-021-02331-1 |
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