Clinicopathological characterisation of myeloproliferative neoplasm‐unclassifiable (MPN‐U): a retrospective analysis from a large UK tertiary referral centre.
In: British Journal of Haematology, Jg. 193 (2021-05-15), Heft 4, S. 792-797
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Summary: Myeloproliferative neoplasm‐unclassifiable (MPN‐U) presents an MPN‐type phenotype that fails to meet diagnostic criteria for other MPN variants. Variability in the clinicopathological phenotypes presents many challenges. Amongst a registry cohort of 1512 patients with MPN, 82 with MPN‐U were included, with a median (range) age of 49·7 (13–79) years. Albeit heterogeneous, common presentation features included raised lactate dehydrogenase, thrombocytosis and clustered/pleomorphic megakaryocytes on trephine biopsy. Thrombosis was common (21%), necessitating vigilance. The median event‐free survival was 11·25 years (95% confidence interval 9·3–not reached), significantly shortened in cases with lower platelet counts (<500 × 109/l) and a leucocytosis (≥12 × 109/l) at presentation. Generation of potential MPN‐U prognostic scores is required. [ABSTRACT FROM AUTHOR]
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Clinicopathological characterisation of myeloproliferative neoplasm‐unclassifiable (MPN‐U): a retrospective analysis from a large UK tertiary referral centre.
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Autor/in / Beteiligte Person: | Deschamps, Paul ; Moonim, Mufaddal ; Radia, Deepti ; Curto‐Garcia, Natalia ; Woodley, Claire ; Bassiony, Sarah ; O'Sullivan, Jennifer ; Harrington, Patrick ; Raj, Kavita ; Francis, Yvonne ; Kordasti, Shahram ; Ali, Sahra ; Harrison, Claire N. ; McLornan, Donal P. |
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Zeitschrift: | British Journal of Haematology, Jg. 193 (2021-05-15), Heft 4, S. 792-797 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0007-1048 (print) |
DOI: | 10.1111/bjh.17375 |
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