New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities.
In: Molecules, Jg. 26 (2021-02-15), Heft 4, S. 836
Online
academicJournal
Zugriff:
Three new polyene compounds, talacyanols A–C (1–3), along with two known compounds, ramulosin (4) and eurothiocin A (5), were isolated from the marine fungus Talaromyces cyanescens derived from a seaweed Caulerpa sp. Structures of 1–5 were established by one-dimensional and two-dimensional (1D/2D) NMR, HR-ESIMS, and the modified Mosher's methods, as well as comparison with previously reported literature data. All the compounds (1–5) were tested for their in vitro cytotoxic and anti-neuroinflammatory activities. Among them, 1 showed moderate cytotoxic activity against a panel of cancer cell lines (HCT-15, NUGC-3, NCI-H23, ACHN, PC-3, and MDA-MB-231) with GI50 values ranging from 44.4 to 91.6 μM, whereas compounds 2 and 5 exhibited anti-neuroinflammatory effect without cytotoxicity against all the tested cell lines. [ABSTRACT FROM AUTHOR]
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New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities.
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Autor/in / Beteiligte Person: | Shin, Hee Jae ; Anh, Cao Van ; Cho, Duk-Yeon ; Choi, Dong-Kug ; Kang, Jong Soon ; Trinh, Phan Thi Hoai ; Choi, Byeoung-Kyu ; Lee, Hwa-Sun ; Šmejkal, Karel |
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Zeitschrift: | Molecules, Jg. 26 (2021-02-15), Heft 4, S. 836 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 1420-3049 (print) |
DOI: | 10.3390/molecules26040836 |
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