A novel mathematical model of AIDS-associated Kaposi's sarcoma: Analysis and optimal control.
In: Biosystems, Jg. 200 (2021-02-01), S. N.PAG
Online
academicJournal
Zugriff:
Kaposi's sarcoma (KS) has been the most common HHV-8 virus-induced neoplasm associated with HIV-1 infection. Although the standard KS therapy has not changed in 20 years, not all cases of KS will respond to the same therapy. The goal of current AIDS-KS treatment modalities is to reconstitute the immune system and suppress HIV-1 replication, but newer treatment modalities are on horizon. There are very few mathematical models that have included HIV-1 viral load (VL) measures, despite VL being a key determinant of treatment outcome. Here we introduce a mathematical model that consolidates the effect of both HIV-1 and HHV-8 VL on KS tumor progression by incorporating low or high VLs into the proliferation terms of the immune cell populations. Regulation of HIV-1/HHV-8 VL and viral reservoir cells is crucial for restoring a patient to an asymptomatic stage. Therefore, an optimal control strategy given by a combined antiretroviral therapy (cART) is derived. The results indicate that the drug treatment strategies are capable of removing the viral reservoirs faster and consequently, the HIV-1 and KS tumor burden is reduced. The predictions of the mathematical model have the potential to offer more effective therapeutic interventions based on viral and virus-infected cell load and support new studies addressing the superiority of VL over CD 4 + T-cell count in HIV-1 pathogenesis. • There are very few within-host mathematical models considering AIDS-associated Kaposi's sacoma (AIDS-KS). • The first model of AIDS-KS that includes viral load (VL) measures despite VL being a key determinant in treatment outcome. • By considering weak and strong viral terms the model is able to capture and predict potential outcomes of AIDS-KS. • The results suggest early treatment for HIV-1 in order to maintain low VL and hence preventing AIDS-KS. [ABSTRACT FROM AUTHOR]
Titel: |
A novel mathematical model of AIDS-associated Kaposi's sarcoma: Analysis and optimal control.
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Autor/in / Beteiligte Person: | Kaondera-Shava, R.F. ; Lungu, E. ; Szomolay, B. |
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Zeitschrift: | Biosystems, Jg. 200 (2021-02-01), S. N.PAG |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0303-2647 (print) |
DOI: | 10.1016/j.biosystems.2020.104318 |
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