Preparation and characterization of C-phycocyanin coated with STMP/STPP cross-linked starches from different botanical sources.
In: International Journal of Biological Macromolecules, Jg. 159 (2020-09-15), S. 739-750
Online
academicJournal
Zugriff:
This work aimed to use sodium trimetaphosphate/sodium tripolyphosphate cross-linked potato, banana, corn, cassava, and breadfruit starches as wall materials for C-phycocyanin encapsulation, characterize them and evaluate their in vivo pharmacological effects in an inflammation model. The cross-linked starches were successfully obtained, characterized, and submitted to C-phycocyanin encapsulation by freeze-drying. The characterization of cross-linked starches-C-phycocyanin composites by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetry, and differential scanning calorimetry demonstrated that the C-phycocyanin was encapsulated between amorphous chains of cross-linked starches. Among the five preparations, the cross-linked potato starch presented the highest phosphorous content (0.084%), substitution degree (0.004), water uptake capacity (0.88 g g−1), and C-phycocyanin encapsulation efficiency (67.58%), thus was tested in vivo. The cross-linked potato starch-C-phycocyanin prolonged the antihyperalgesic effects attributed to C-phycocyanin, evaluated by complete Freund's adjuvant (CFA) model. Starch cross-linking promoted the formation of a hydrogel network in swollen state entrapping C-phycocyanin, thus, acting as a barrier to its release to the medium and promoting long-lasting in vivo effects. The combination of chemical modification of starches followed by physical treatment presented itself as a useful tool for the development of pharmaceutical formulations. Unlabelled Image • Five starches were cross-linked using STMP/STPP reagents. • Cross-linked starches-C-phycocyanin composites were successfully obtained. • The supramolecular structures were characterized by SEM, FTIR, XRD, TG and DSC techniques. • Prolonged antihyperalgesic effects of C-phycocyanin were noticed in vivo. [ABSTRACT FROM AUTHOR]
Titel: |
Preparation and characterization of C-phycocyanin coated with STMP/STPP cross-linked starches from different botanical sources.
|
---|---|
Autor/in / Beteiligte Person: | Lemos, Paulo Vitor França ; Opretzka, Luiza Carolina Franca ; Almeida, Letícia Santos ; Cardoso, Lucas Guimarães ; Silva, Jania Betânia Alves da ; Souza, Carolina Oliveira de ; Villarreal, Cristiane Flora ; Druzian, Janice Izabel |
Link: | |
Zeitschrift: | International Journal of Biological Macromolecules, Jg. 159 (2020-09-15), S. 739-750 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 0141-8130 (print) |
DOI: | 10.1016/j.ijbiomac.2020.05.111 |
Schlagwort: |
|
Sonstiges: |
|