Mechanochemistry for the production of a hybrid salt used in the treatment of malaria.
In: Green Chemistry, Jg. 22 (2020-01-07), Heft 1, S. 54-61
Online
academicJournal
Zugriff:
Mechanochemistry refers to a chemical reaction induced by mechanical energy involving solids. This method provides several advantages over solution-phase synthesis, such as minimizing the need for large volumes of solvents in chemical reactions and greener and more efficient synthetic solutions. In this paper we obtain, via mechanochemistry, a hybrid salt, named MEFAS, derived from two antimalarial molecules – mefloquine and artesunate. We demonstrate, using a simple experimental procedure, how the catalytic amount of liquid present during mechanochemical reactions is decisive to obtain MEFAS. Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) data indicate that liquid-assisted mechanochemical reactions are promising in the formation of the hybrid salt, which is formed via a hydrogen interaction of the carboxylate group of the artesunate molecule with the piperidine group of mefloquine. [ABSTRACT FROM AUTHOR]
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Mechanochemistry for the production of a hybrid salt used in the treatment of malaria.
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Autor/in / Beteiligte Person: | do Prado, VÃnia M. ; de Queiroz, Thiago B. ; Sá, Paula M. ; Seiceira, Rafael C. ; Boechat, Nubia ; Ferreira, Fabio F. |
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Zeitschrift: | Green Chemistry, Jg. 22 (2020-01-07), Heft 1, S. 54-61 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1463-9262 (print) |
DOI: | 10.1039/c9gc02478f |
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