Non-Ashkenazi Jewish Origin is Associated with Early Onset Alzheimer's Disease.
In: Journal of Alzheimer's Disease, Jg. 65 (2018-08-01), Heft 3, S. 877-884
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Zugriff:
Early-onset Alzheimer's disease (EOAD) accounts for 1-5% of Alzheimer's disease cases and is associated with specific ethnicities. It has been our impression that non-Ashkenazi Jews have a higher rate of EOAD and we therefore explored this hypothesis. We performed a retrospective case control study of EOAD cases referred to our cognitive neurology clinic between January 1999 and December 2016. Patients (n = 129) were compared to age- and geographically-matched controls generated from the Second Israeli National Health Survey (n = 1,811). Data on country of origin, education, dementia family history, depression, and vascular risk factors were compared between the groups. The association of non-Ashkenazi Jewish heritage and country of origin with EOAD was calculated using a logistic multivariate regression model. The EOAD group's mean age was 59.6±4.1 years, with a female predominance (64.3%). The EOAD group had a higher percentage of individuals of non-Ashkenazi Jewish origin (64.3% versus 51.4%, p = 0.003) and of Yemenite descent in particular (16.28% versus 6.24%, p < 0.001). On multiple logistic regression analysis, Yemenite Jewish origin was an independently associated with EOAD (OR 2.54, 95% CI 1.4-4.8). There were no significant differences in parameters between non-Ashkenazi and Ashkenazi Jews. Only 4.6% of EOAD cases had a positive EOAD family history. In conclusion, EOAD is over-represented among non-Ashkenazi Jews. Yemenite origin is independently associated with EOAD and the majority of patients with EOAD have no family history of Alzheimer's disease. Further evaluation with genetic studies is warranted. [ABSTRACT FROM AUTHOR]
Titel: |
Non-Ashkenazi Jewish Origin is Associated with Early Onset Alzheimer's Disease.
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Autor/in / Beteiligte Person: | Keret, Ophir ; Shochat, Tzippy ; Steiner, Israel ; Glik, Amir |
Zeitschrift: | Journal of Alzheimer's Disease, Jg. 65 (2018-08-01), Heft 3, S. 877-884 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 1387-2877 (print) |
DOI: | 10.3233/JAD-180331 |
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