Porcine circovirus type 2 inhibits inter-β expression by targeting Karyopherin alpha-3 in PK-15 cells.
In: Virology, Jg. 520 (2018-07-01), S. 75-82
Online
academicJournal
Zugriff:
Interferon (IFN)-mediated antiviral response is an important part of host defense. Previous studies reported that porcine circovirus type 2 (PCV2) inhibits interferon production, but the mechanism is still poorly understood. In this study, PCV2 suppresses IFN-β and IRF3 promoters and mRNA level of IFN-β induced by ISD or Poly(I:C), but has no effect on the activation of AP-1 and NF-κB. Furthermore, PCV2 decreases the mRNA level of IFN-β and IFN-β promoter activity driven by STING, TBK1, IRF3, and IRF3/5D, and causes a reduction in the protein level of nuclear p-IRF3. In addition, PCV2 interrupts the interaction of KPNA3, rather than KPNA4, with p-IRF3. Overexpression of KPNA3 restores IFN-β promoter activity. These results indicate that PCV2 disrupts the interaction of KPNA3 with p-IRF3 and blocks p-IRF3 translocation to the nucleus, thereby inhibiting IFN-β induction in PK-15 cells. [ABSTRACT FROM AUTHOR]
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Porcine circovirus type 2 inhibits inter-β expression by targeting Karyopherin alpha-3 in PK-15 cells.
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Autor/in / Beteiligte Person: | Li, Jiansheng ; Lu, Mingqing ; Huang, Bei ; Lv, Yingjun |
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Zeitschrift: | Virology, Jg. 520 (2018-07-01), S. 75-82 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 0042-6822 (print) |
DOI: | 10.1016/j.virol.2018.05.008 |
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