Njaoamine I, a cytotoxic polycyclic alkaloid from the Haplosclerida sponge Haliclona (Reniera) sp.
In: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry, Jg. 59 (2018-06-27), Heft 26, S. 2577-2580
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Zugriff:
A new cytotoxic polycyclic alkaloid containing a quinoline moiety, njaoamine I ( 1 ) has been isolated from the methanol extract of the sponge Haliclona ( Reniera ) sp. collected at Okuza Island, Tanzania. The structure of compound 1 was determined by 1D and 2D NMR and HRMS data analysis. Its relative configuration was elucidated by a NOESY experiment and confirmed by comparison of its NMR spectral data to those of njaoamines A–H. Moreover, njaoamine G ( 2 ) was also detected by LC/MS analysis of the methanol extract. Njaoamine I ( 1 ) displays cytotoxic activity against a panel of three human tumor cell lines in the micromolar range. [ABSTRACT FROM AUTHOR]
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Njaoamine I, a cytotoxic polycyclic alkaloid from the Haplosclerida sponge Haliclona (Reniera) sp.
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Autor/in / Beteiligte Person: | Urda, Carlos ; Pérez, Marta ; Rodríguez, Jaime ; Fernández, Rogelio ; Jiménez, Carlos ; Cuevas, Carmen |
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Zeitschrift: | Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry, Jg. 59 (2018-06-27), Heft 26, S. 2577-2580 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 0040-4039 (print) |
DOI: | 10.1016/j.tetlet.2018.05.059 |
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