Dehydrogenative Cross-Coupling Reaction between N-Aryl α-Amino Acid Esters and Phenols or Phenol Derivative for Synthesis of α-Aryl α-Amino Acid Esters.
In: Organic Letters, Jg. 18 (2016-04-01), Heft 7, S. 1526-1529
Online
academicJournal
Zugriff:
A novel dehydrogenative cross-coupling (DCC) reaction between N-arylglycine esters and phenols or 1,3,5-trimethoxybenzene was developed by copper catalysis using di-tert-butyl peroxide (DTBP) as an oxidant. Under optimized conditions, a range of N-arylglycine esters 1 underwent the DCC reaction smoothly with various phenols 2 or 1,3,5-trimethoxybenzene 4 to give desired α-aryl α-amino acid esters 3 or 5 , respectively, with high ortho regioselectivities in a moderate to excellent yield. A possible mechanism involving aromatic electrophilic substitution is proposed. [ABSTRACT FROM AUTHOR]
Titel: |
Dehydrogenative Cross-Coupling Reaction between N-Aryl α-Amino Acid Esters and Phenols or Phenol Derivative for Synthesis of α-Aryl α-Amino Acid Esters.
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Autor/in / Beteiligte Person: | Salman, Muhammad ; Zhu, Zhi-Qiang ; Huang, Zhi-Zhen |
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Zeitschrift: | Organic Letters, Jg. 18 (2016-04-01), Heft 7, S. 1526-1529 |
Veröffentlichung: | 2016 |
Medientyp: | academicJournal |
ISSN: | 1523-7060 (print) |
DOI: | 10.1021/acs.orglett.6b00162 |
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