DIAGNOSTIC ROLE OF FLUORINE-18 (<superscript>18</superscript>F) FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY COMPUTED TOMOGRAPHY IN DETECTING RECURRENT DISEASE IN PATIENTS WITH COLORECTAL CANCER AND ELEVATED CARCINOEMBRYONIC ANTIGEN.
In: Medical Review / Medicinski Pregled, Jg. 68 (2015-11-01), Heft 11/12, S. 376-381
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Zugriff:
Introduction. Early detection of recurrence is an important factor for long term survival of patients with colorectal cancer. Measurement of serum levels of carcinoembryonic antigen has been commonly used in the postoperative surveillance of colorectal cancer. The purpose of this study was to evaluate the ability of positron emission tomography-computed tomography to detect pathological substrate of elevated serum carcinoembryonic antigen in patients with colorectal cancer. Material and Methods. The patients with colorectal cancer who underwent curative surgical resection and/ or chemotherapy, who were found in our database, were analyzed retrospectively. Forty-eight 18F- fluorodeoxyglucose positron emission tomography-computed tomography studies including 45 patients (14 women, 31 men; mean age: 62.93 years) with elevated serum, carcinoembryonic antigen levels, which had been performed between January 2011 and January 2014, were evaluated. Serum levels of carcinoembryonic antigen were measured within 3 months after positron emission tomography-computed tomography examination. Final diagnosis of recurrence was made by histopathological findings, radiology studies or clinical follow-up. Results. Recurrences were diagnosed in 37 patients, the prevalence being 77.1%. Liver metastases were found in 18 patients, abdominal, pelvic and/or mediastinal lymph nodes were positive in 19 patients, 11 patients had loco regional recurrences and 4 patients had pulmonary metastasis, and bone metastases were found in one patient. One patient was diagnosed with metastasis in scar tissue. The overall sensitivity and specificity of positron emission tomography-computed tomography was 90.24% and 71.42%, respectively. The positive and negative predictive values were 94.87% and 55.56%, respectively. Conclusion. 18F- fluorodeoxyglucose positron emission tomography-computed tomography is a powerful tool that could be used in determining colorectal cancer recurrence in patients with elevated carcinoembryonic antigen levels and could have an important clinical impact on the management in patients with suspected recurrent colorectal cancer. [ABSTRACT FROM AUTHOR]
Uvod. Rano otkrivanje recidiva je važan činilac za dugoročno preživljavanje bolesnika sa kolorektalnim karcinomom. Merenje serumske koncentracije karcinoembrionskog antigena uobičajeno se koristi u postoperativnom praćenju ovih pacijenata. Cilj istraživanja bio je proceniti sposobnosti pozitron emisione tomografije/kompjuterizovane tomografije za otkrivanje patološkog supstrata povišenog karcinoembrionskog antigena kod bolesnika sa kolorektalnim karcinomom. Materijal i metode. Bolesnici sa kolorektalnim karcinomom koji su bili podvrgnuti kurativnoj hirurškoj resekciji kao i eventualnoj hemioterapiji su retroaktivno pretraživani u našoj bazi podataka. Ukupno je evaluirano 48 pozitron emisionih tomografija/kompjuterizovanih tomografija F18 fluorodezoksi glukozom studija načinjenih u periodu između januara 2011. i januara 2014. godine 45 bolesnika (14 žena, 31 muškarac, prosečne starosti: 62,93 godine) s povišenim koncentracijama karcinoembrionskog antigena. Merenje serumskih koncentracija karcinoembrionskog antigena sprovedeno je unutar 3 meseca od pozitron emisione tomografije/kompjuterizovane tomografije. Konačna dijagnoza recidiva je potvrđena na osnovu histopatološkog nalaza, radioloških studija ili kliničkog praćenja. Rezultati. Recidiv bolesti registrovan je kod 37 bolesnika (prevalencija 77,1%). Hepatične metastaze pronađene su kod 18 pacijenata, limfni čvorovi abdomena, karlicei/ili medijastinuma bili su pozitivni kod 19 pacijenata, lokoregionalni recidivi pronađeni su kod 11 pacijenata, plućne metastaze kod 4 pacijenta, a dok su koštane metastaze pronađene kod samo jednog pacijenta. Takođe kod jednog pacijenta metastaza je registrovana unutar postoperativnog ožiljka kože. Sveukupna osjetljivost, specifičnost pozitron emisione tomografije/kompjuterizovane tomografije je 90,24% i 71,42%, respektivno. Pozitivne i negativne prediktivne vrednosti bile su 94,87% i 55,56% respektivno. Zaključak. Pozitron emisiona tomografija/kompjuterizovana tomografija 18F-fluorodezoksi glukozom je moćan “alat” koji bi se mogao koristiti u određivanju recidiva kolorektalnog karcinoma kod bolesnika sa povišenim koncentracijama karcinoembrionskog antigena i takođe bi mogao imati važan uticaj na klinički tretman pacijenata sa suspektnim recidivom ove bolesti. [ABSTRACT FROM AUTHOR]
Titel: |
DIAGNOSTIC ROLE OF FLUORINE-18 (<superscript>18</superscript>F) FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY COMPUTED TOMOGRAPHY IN DETECTING RECURRENT DISEASE IN PATIENTS WITH COLORECTAL CANCER AND ELEVATED CARCINOEMBRYONIC ANTIGEN.
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Autor/in / Beteiligte Person: | MATOVINA, Emil ; MIHAILOVIĆ, Jasna ; NIKOLETIĆ, Katarina ; SRBOVAN, Dolores |
Zeitschrift: | Medical Review / Medicinski Pregled, Jg. 68 (2015-11-01), Heft 11/12, S. 376-381 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 0025-8105 (print) |
DOI: | 10.2298/MPNS1512376M |
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