Design and Evaluation of aRobust PID Controller for a Fully ImplantableArtificial Pancreas.

Treatment of type 1 diabetes mellituscould be greatly improvedby applying a closed-loop control strategy to insulin delivery, alsoknown as an artificial pancreas (AP). In this work, we outline thedesign of a fully implantable AP using intraperitoneal (IP) insulindelivery and glucose sensing. The design process utilizes the rapidglucose sensing and insulin action offered by the IP space to tunea PID controller with insulin feedback to provide safe and effectiveinsulin delivery. The controller was tuned to meet robust performanceand stability specifications. An anti-reset windup strategy was introducedto prevent dangerous undershoot toward hypoglycemia after a largemeal disturbance. The final controller design achieved 78% of timewithin the tight glycemic range of 80–140 mg/dL, with no timespent in hypoglycemia. The next step is to test this controller designin an animal model to evaluate the in vivoperformance. [ABSTRACT FROM AUTHOR]