Association of estrogen receptor alpha and beta3-adrenergic receptor polymorphisms with endometrial cancer.
In: Obstetrics & Gynecology, Jg. 102 (2003-09-01), Heft 3, S. 506-511
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Zugriff:
Objective: To investigate the association of estrogen receptor alpha and beta3-adrenergic receptor polymorphisms with endometrial cancer risk in Kagoshima, Japan. Methods: Ninety-two patients with endometrial cancer and 65 healthy women were enrolled in this study. Blood samples were collected, and deoxyribonucleic acid (DNA) was extracted. Estrogen receptor alpha and beta3-adrenergic receptor gene variants were analyzed by restriction fragment length polymorphisms using the restriction enzymes, Pvu II, Xba I for estrogen receptor alpha, and Mva I for beta3-adrenergic receptor. Multivariable logistic regression analysis was performed, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Results: The Pvu II PP genotype was associated with a decreased risk of endometrial cancer (multivariable OR 0.23; 95% CI 0.07, 0.82) compared with the pp genotype. The Xba I XX genotype was associated with a decreased risk for endometrial cancer (multivariable OR 0.26; 95% CI 0.09, 0.79) compared with the xx genotype. The Mva I variants were not associated with endometrial cancer risk (multivariable OR 0.55; 95% CI 0.20, 1.51). Conclusion: Estrogen receptor alpha polymorphisms, but not beta3-adrenergic receptor gene, may be associated with a risk of endometrial cancer. [ABSTRACT FROM AUTHOR]
Titel: |
Association of estrogen receptor alpha and beta3-adrenergic receptor polymorphisms with endometrial cancer.
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Autor/in / Beteiligte Person: | Iwamoto, I ; Fujino, T ; Douchi, T ; Nagata, Y ; Iwamoto, Ichiro ; Fujino, Toshinori ; Douchi, Tsutomu ; Nagata, Yukihiro |
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Zeitschrift: | Obstetrics & Gynecology, Jg. 102 (2003-09-01), Heft 3, S. 506-511 |
Veröffentlichung: | 2003 |
Medientyp: | academicJournal |
ISSN: | 0029-7844 (print) |
DOI: | 10.1016/s0029-7844(03)00578-7 |
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