Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production.
In: Journal of Infectious Diseases, Jg. 198 (2008-10-15), Heft 8, S. 1219-1226
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Zugriff:
Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1beta promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level <6.0 g/dL), and circulating IL-1beta levels were investigated in children with parasitemia (n= 566) from western Kenya. The IL-1beta promoter haplotype -31C/-511A (CA) was associated with increased risk of SMA (Hb level <6.0 g/dL; odds ratio [OR], 1.98 [95% confidence interval {CI}, 1.55-2.27]; P < .05) and reduced circulating IL-1beta levels (p <.05). The TA (-31T/-511A) haplotype was nonsignificantly associated with protection against SMA (OR, 0.52 [95% CI, 0.18-1.16]; p =.11) and elevated IL-1beta production ( p<.05). Compared with the non-SMA group, children with SMA had significantly lower IL-1beta levels and nonsignificant elevations in both IL-1 receptor antagonist (IL-1Ra) and the ratio of IL-1Ra to IL-1beta. The results presented demonstrate that variation in IL-1beta promoter conditions susceptibility to SMA and functional changes in circulating IL-1beta levels. [ABSTRACT FROM AUTHOR]
Titel: |
Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production.
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Autor/in / Beteiligte Person: | Ouma, C ; Davenport, GC ; Awandare, GA ; Keller, CC ; Were, T ; Otieno, MF ; Vulule, JM ; Martinson, J ; Ong'echa, JM ; Ferrell, RE ; Perkins, DJ ; Ouma, Collins ; Davenport, Gregory C ; Awandare, Gordon A ; Keller, Christopher C ; Were, Tom ; Otieno, Michael F ; Vulule, John M ; Martinson, Jeremy ; Ong'echa, John M |
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Zeitschrift: | Journal of Infectious Diseases, Jg. 198 (2008-10-15), Heft 8, S. 1219-1226 |
Veröffentlichung: | 2008 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1086/592055 |
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