Active Renal Secretion of NXY-059, a Novel Neuroprotectant, Is Mediated via an Organic Acid Transporter.
In: Journal of Clinical Pharmacology, Jg. 47 (2007-07-01), Heft 7, S. 909-914
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academicJournal
Zugriff:
The article discusses a study which highlighted that healthy subjects receiving intravenous (iv) infusions of novel neuroprotectant (NXY-059) is mainly eliminated unchanged by renal excretion. It discusses whether NXY-059 uses the active secretory pathway for acids or bases, using inhibitors of these pathways, probenecid and cimetidine, respectively.
Titel: |
Active Renal Secretion of NXY-059, a Novel Neuroprotectant, Is Mediated via an Organic Acid Transporter.
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Autor/in / Beteiligte Person: | Cheng, Yi-Fang ; Strid, Stig ; Borgå, Olof ; Nilsson, Dag ; Wemer, Johan |
Link: | |
Zeitschrift: | Journal of Clinical Pharmacology, Jg. 47 (2007-07-01), Heft 7, S. 909-914 |
Veröffentlichung: | 2007 |
Medientyp: | academicJournal |
ISSN: | 0091-2700 (print) |
DOI: | 10.1177/0091270007301803 |
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